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Medical lung diseases (view source)
Revision as of 03:50, 13 November 2011
, 03:50, 13 November 2011→Obliterative broncholitis: more
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**[http://www.flickr.com/photos/pulmonary_pathology/4733384977/ Masson body (flickr.com)]. | **[http://www.flickr.com/photos/pulmonary_pathology/4733384977/ Masson body (flickr.com)]. | ||
== | ==Constrictive bronchiolitis== | ||
*[[AKA]] ''bronchiolitis obliterans'', [[AKA]] ''obliterative broncholitis'',<ref name=pmid16493150/> [[AKA]] bronchiolitis obliterans syndrome (BOS).<ref name=pmid18707652>{{Cite journal | last1 = Sato | first1 = M. | last2 = Keshavjee | first2 = S. | title = Bronchiolitis obliterans syndrome: alloimmune-dependent and -independent injury with aberrant tissue remodeling. | journal = Semin Thorac Cardiovasc Surg | volume = 20 | issue = 2 | pages = 173-82 | month = | year = 2008 | doi = 10.1053/j.semtcvs.2008.05.002 | PMID = 18707652 }}</ref> | |||
===General=== | ===General=== | ||
* | *'''''Not''''' the same as ''Bronchiolitis obliterans organizing pneumonia (BOOP)'' - in short: | ||
**BOOP: clogs the airway, has Masson bodies, treated with steroids - good prognosis. | |||
**Constrictive bronchiolitis: fibrosis around airways, crappy prognosis. | |||
*No good treatment. | |||
*Progressive. | |||
Etiology/associations:<ref name=pmid16493150/> | |||
*Post-infectious. | |||
**Viral. | |||
**Mycoplasma. | |||
*Post-lung transplant.<ref name=pmid19896545/> | |||
*Post-hematopoietic stem cell transplantation | |||
**Associated with GVHD.<ref name=pmid19896545>{{Cite journal | last1 = Chien | first1 = JW. | last2 = Duncan | first2 = S. | last3 = Williams | first3 = KM. | last4 = Pavletic | first4 = SZ. | title = Bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation-an increasingly recognized manifestation of chronic graft-versus-host disease. | journal = Biol Blood Marrow Transplant | volume = 16 | issue = 1 Suppl | pages = S106-14 | month = Jan | year = 2010 | doi = 10.1016/j.bbmt.2009.11.002 | PMID = 19896545 }}</ref> | |||
*Connective tissue disease, mostly [[rheumatoid arthritis]]. | |||
*[[Ulcerative colitis]]. | |||
*Drugs - penicillamine. | |||
*Toxins. | |||
*Idiopathic. | |||
===Microscopic=== | |||
Features:<ref name=pmid16493150>{{Cite journal | last1 = Visscher | first1 = DW. | last2 = Myers | first2 = JL. | title = Bronchiolitis: the pathologist's perspective. | journal = Proc Am Thorac Soc | volume = 3 | issue = 1 | pages = 41-7 | month = | year = 2006 | doi = 10.1513/pats.200512-124JH | PMID = 16493150 | url = http://pats.atsjournals.org/cgi/content/full/3/1/41 }}</ref> | |||
#Bronchiolitis - mononuclear and neutrophilic. | |||
#*May be minimal late in the disease. | |||
#Fibrosis - submucosal and peribronchiolar. | |||
#*Can be patchy. | |||
Notes: | |||
*Bronchioles = noncartilagenous airways usu. < 2 mm in diameter.<ref name=pmid16493150/> | |||
Images: | |||
*[http://pats.atsjournals.org/cgi/content/full/3/1/41/FIG4 Constrictive bronchiolitis (atsjournals.org)]. | |||
===Stains=== | |||
*Elastic trichrome - useful for delineation of obliterated bronchioles. | |||
==Diffuse lung diseases== | ==Diffuse lung diseases== | ||