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Difference between revisions of "Salivary glands"
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→Sebaceous carcinoma: +hyalinizing clear cell carcinoma
(→Microscopic: more iamges) |
(→Sebaceous carcinoma: +hyalinizing clear cell carcinoma) |
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| Line 848: | Line 848: | ||
{{Main|Sebaceous carcinoma}} | {{Main|Sebaceous carcinoma}} | ||
It is similar to the tumour found in the skin. | It is similar to the tumour found in the skin. | ||
==Hyalinizing clear cell carcinoma== | |||
*Abbreviated ''HCCC''. | |||
===General=== | |||
*Rare. | |||
*Good prognosis.<ref>{{Cite journal | last1 = Masilamani | first1 = S. | last2 = Rao | first2 = S. | last3 = Chirakkal | first3 = P. | last4 = Kumar | first4 = AR. | title = Hyalinizing clear cell carcinoma of the base of tongue: a distinct and rare entity. | journal = Indian J Pathol Microbiol | volume = 54 | issue = 1 | pages = 167-9 | month = | year = | doi = 10.4103/0377-4929.77393 | PMID = 21393908 }}</ref> | |||
===Microscopic=== | |||
Features:<ref name=pmid20596970>{{Cite journal | last1 = O'Sullivan-Mejia | first1 = ED. | last2 = Massey | first2 = HD. | last3 = Faquin | first3 = WC. | last4 = Powers | first4 = CN. | title = Hyalinizing clear cell carcinoma: report of eight cases and a review of literature. | journal = Head Neck Pathol | volume = 3 | issue = 3 | pages = 179-85 | month = Sep | year = 2009 | doi = 10.1007/s12105-009-0124-3 | PMID = 20596970 }}</ref> | |||
*Groups of cells with abundant clear cytoplasm. | |||
**Arranged in cords, trabecuae or clusters. | |||
*Hyalinized stroma. | |||
DDx: | |||
*[[Mucoepidermoid carcinoma]], clear cell variant. | |||
*[[Acinic cell carcinoma]], clear cell variant. | |||
*Metastatic [[clear cell renal cell carcinoma]]. | |||
**Classically have hemorrhage & [[necrosis]]. | |||
*[[Epithelial-myoepithelial carcinoma]]. | |||
Images: | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811632/figure/Fig2/ HCCC (nlm.nih.gov)]. | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811632/figure/Fig5/ HCCC (nlm.nih.gov)].<ref name=pmid20596970/> | |||
===Stains/IHC=== | |||
*PAS +ve. | |||
*AE1/AE3 +ve. | |||
*Desmin -ve. | |||
*SMA -ve. | |||
*S-100 -ve. | |||
===Molecular=== | |||
Recurrent [[translocation]]:<ref name=pmid21484932>{{Cite journal | last1 = Antonescu | first1 = CR. | last2 = Katabi | first2 = N. | last3 = Zhang | first3 = L. | last4 = Sung | first4 = YS. | last5 = Seethala | first5 = RR. | last6 = Jordan | first6 = RC. | last7 = Perez-Ordoñez | first7 = B. | last8 = Have | first8 = C. | last9 = Asa | first9 = SL. | title = EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland. | journal = Genes Chromosomes Cancer | volume = 50 | issue = 7 | pages = 559-70 | month = Jul | year = 2011 | doi = 10.1002/gcc.20881 | PMID = 21484932 }}</ref> | |||
*EWSR1-ATF1. | |||
=See also= | =See also= | ||