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Difference between revisions of "Endometrial carcinoma"
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→Endometrioid endometrial carcinoma: more
(re-work, subdivide) |
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=Specific types= | =Specific types= | ||
==Endometrioid endometrial carcinoma== | ==Endometrioid endometrial carcinoma== | ||
*[[AKA]] ''endometrioid endometrial adenocarcinoma'' | |||
**Has gland formation. | |||
===General=== | |||
*Good prognosis - usually. | |||
*Women in 40s & 50s. | |||
*Assoc. with estrogen excess. | |||
**Typical patient is obese. | |||
===Microscopic=== | ===Microscopic=== | ||
Features - endometrioid: | Features - endometrioid: | ||
*Tubular glands. | *Tubular glands. | ||
**Usually well-formed. | |||
*Squamous metaplasia. | *Squamous metaplasia. | ||
**Look for ''squamous morules'': | **Look for ''squamous morules'': | ||
**Ball of cells with intensely eosinophilic cytoplasm | ***Ball of cells with an intensely eosinophilic cytoplasm - '''key feature'''. | ||
***Central nucleus. | |||
***Intercellular bridges - may be hard to find. | |||
***+/-Dyskeratotic cells. | |||
Notes: | Notes: | ||
*Dyskeratosis = abnormal keratinization;<ref>URL: [http://dictionary.reference.com/browse/dyskeratosis http://dictionary.reference.com/browse/dyskeratosis]. Accessed on: 5 September 2011.</ref> classically have intensely eosinophilic cytoplasm +/- nuclear fragmentation ([http://dictionary.reference.com/browse/karyolysis?db=medical&q=karyolysis karyorrhexis]) - see: [http://www.drmihm.com/pictures/Figure%203.jpg several dyskeratotic cells]. | *Dyskeratosis = abnormal keratinization;<ref>URL: [http://dictionary.reference.com/browse/dyskeratosis http://dictionary.reference.com/browse/dyskeratosis]. Accessed on: 5 September 2011.</ref> classically have intensely eosinophilic cytoplasm +/- nuclear fragmentation ([http://dictionary.reference.com/browse/karyolysis?db=medical&q=karyolysis karyorrhexis]) - see: [http://www.drmihm.com/pictures/Figure%203.jpg several dyskeratotic cells]. | ||
*Squamous morules in endometrioid endometrial carcinoma - not assoc. with HPV infection.<ref name=pmid15333650>{{Cite journal | last1 = Chinen | first1 = K. | last2 = Kamiyama | first2 = K. | last3 = Kinjo | first3 = T. | last4 = Arasaki | first4 = A. | last5 = Ihama | first5 = Y. | last6 = Hamada | first6 = T. | last7 = Iwamasa | first7 = T. | title = Morules in endometrial carcinoma and benign endometrial lesions differ from squamous differentiation tissue and are not infected with human papillomavirus. | journal = J Clin Pathol | volume = 57 | issue = 9 | pages = 918-26 | month = Sep | year = 2004 | doi = 10.1136/jcp.2004.017996 | PMID = 15333650 }}</ref> | |||
Image: | |||
*[http://www.diagnosticpathology.org/content/2/1/40/figure/F1?highres=y Squamous morule with dyskeratotic cell (diagnosticpathology.org)]. | |||
==Serous endometrial carcinoma== | ==Serous endometrial carcinoma== | ||