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m (→Arteriolar hyalinosis: re-arr.) |
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Line 259: | Line 259: | ||
*Lupus. | *Lupus. | ||
===Bland necrotic crescents=== | ===Crescents=== | ||
*Indicate a rapidly progressive disease. | |||
*Etiology/definition: break in the glomerular basement membrane (GBM). | |||
Microscopic: | |||
*Break in the glomerular basement membrane - '''key feature'''. | |||
**Best seen on a silver stain (e.g. [[Jones stain]]). | |||
*Fibrin. | |||
**Described as orange on [[HPS stain|HPS]]. | |||
*Cellular debris. | |||
*Inflammatory cells (lymphocytes, plasma cells, eosinophils, macrophages). | |||
====Bland necrotic crescents==== | |||
DDx: | DDx: | ||
*ANCA-related glomerulonephritis. | *ANCA-related glomerulonephritis. |
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