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==Membranoproliferative glomerulonephritis== | ==Membranoproliferative glomerulonephritis== | ||
*Abbreviated ''MPGN''. | |||
*Old name ''MPGN type 1''. | |||
===General=== | ===General=== | ||
*In adults most common cause: ''hepatitis C''. | *In adults most common cause: ''hepatitis C''. | ||
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*Basement membrane double layering (tram-tracking). | *Basement membrane double layering (tram-tracking). | ||
*Mesangial hypercellularity. | *Mesangial hypercellularity. | ||
==Dense deposition disease== | |||
*Abbreviated ''DDD'''. | |||
*Old name ''MPGN type 2''. | |||
===General=== | |||
*Usually children and young adults. | |||
===Microscopic=== | |||
Features: | |||
*Variable - may be like MPGN. | |||
===IF=== | |||
*Linear C3 with mesangial rings (donut-like). | |||
*IgG negative. | |||
*IgA negative | |||
===EM=== | |||
*Electron dense transformation of GBM lamina densa - key feature. | |||
**Dense = darker. | |||
=Nephritic syndrome= | =Nephritic syndrome= |
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