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Difference between revisions of "Endometrial carcinoma"
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*Dyskeratosis = abnormal keratinization;<ref>[http://dictionary.reference.com/browse/dyskeratosis http://dictionary.reference.com/browse/dyskeratosis]</ref> classically have intensely eosinophilic cytoplasm +/- nuclear fragmentation ([http://dictionary.reference.com/browse/karyolysis?db=medical&q=karyolysis karyorrhexis]) - see: [http://www.drmihm.com/pictures/Figure%203.jpg several dyskeratotic cells]. | *Dyskeratosis = abnormal keratinization;<ref>[http://dictionary.reference.com/browse/dyskeratosis http://dictionary.reference.com/browse/dyskeratosis]</ref> classically have intensely eosinophilic cytoplasm +/- nuclear fragmentation ([http://dictionary.reference.com/browse/karyolysis?db=medical&q=karyolysis karyorrhexis]) - see: [http://www.drmihm.com/pictures/Figure%203.jpg several dyskeratotic cells]. | ||
==Grading (FIGO)== | ==Grading (FIGO)== | ||
*Based on gland formation & adjusted by nuclear pleomorphism:<ref>PBoD | *Based on gland formation & adjusted by nuclear pleomorphism:<ref>{{Ref PBoD|1087-8}}</ref><ref>[http://www.pathologyoutlines.com/uterus.html#endometrialcarc][http://www.emedicine.com/med/topic2832.htm][http://www.ncbi.nlm.nih.gov/pubmed/12496701]</ref> | ||
**Grade 1: <5% solid component. | **Grade 1: <5% solid component. | ||
**Grade 2: 5-50% solid component. | **Grade 2: 5-50% solid component. | ||
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**IVa = bladder or bowel mucosa. | **IVa = bladder or bowel mucosa. | ||
**IVb = distant mets (intraabdominal, inguinal nodes). | **IVb = distant mets (intraabdominal, inguinal nodes). | ||
Ref: <ref>PBoD | Ref: <ref>{{Ref PBoD|1088}}</ref>, <ref>[http://www.emedicine.com/med/topic2832.htm http://www.emedicine.com/med/topic2832.htm]</ref> | ||
<ref>[http://www.cancerfacts.com/GeneralContent/Uterine/Gen_Diagnosis.asp?CB=11 - Staging with groovy graphics]</ref> | <ref>[http://www.cancerfacts.com/GeneralContent/Uterine/Gen_Diagnosis.asp?CB=11 - Staging with groovy graphics]</ref> | ||