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Difference between revisions of "Pancreas"
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→Pancreatic intraepithelial neoplasia (PanIN): format
(→Subclassication: repl. ref. cystadenoca.) |
m (→Pancreatic intraepithelial neoplasia (PanIN): format) |
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Memory device ''PCB'': '''P'''R (nuclear), '''C'''D10 (cytoplasmic), '''b'''eta-catenin (cytoplasmic & nuclear). | Memory device ''PCB'': '''P'''R (nuclear), '''C'''D10 (cytoplasmic), '''b'''eta-catenin (cytoplasmic & nuclear). | ||
==Pancreatic intraepithelial neoplasia | ==Pancreatic intraepithelial neoplasia== | ||
*Abbreviated ''PanIN''. | |||
===General=== | |||
*PanIN is thought to be the precursor lesion for pancreatic carcinoma.<ref name=Ref_PBoD949>{{Ref PBoD|949}}</ref> | *PanIN is thought to be the precursor lesion for pancreatic carcinoma.<ref name=Ref_PBoD949>{{Ref PBoD|949}}</ref> | ||
===Overview=== | ====Overview==== | ||
Putative preneoplasm-neoplasm-carcinoma sequence: | Putative preneoplasm-neoplasm-carcinoma sequence: | ||
*PanIN1a. | *PanIN1a. | ||
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**Can be thought of as ''high-grade dysplasia'', e.g. ''(colonic) villous adenoma''. | **Can be thought of as ''high-grade dysplasia'', e.g. ''(colonic) villous adenoma''. | ||
=== | ===Microscopic=== | ||
Features:<ref name=Ref_PBoD949>{{Ref PBoD|949}}</ref> | Features:<ref name=Ref_PBoD949>{{Ref PBoD|949}}</ref> | ||
*PanIN1a - increased amount of cytoplasm. | *PanIN1a - increased amount of cytoplasm. | ||