Difference between revisions of "Diffuse large B-cell lymphoma"

Diffuse large B-cell lymphoma (view source)

1,306 bytes added , 03:00, 17 October 2011

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 ==IHC==
+===Subclassification===
+There is a subclassification based on molecular testing:
+#Germinal centre (GC) subtype.
+#Non-germinal centre (Non-GC) subtype.
+The following IHC algorithm has been subsequently developed to reproduce the molecular categorization:<ref>{{Cite journal  | last1 = Choi | first1 = WW. | last2 = Weisenburger | first2 = DD. | last3 = Greiner | first3 = TC. | last4 = Piris | first4 = MA. | last5 = Banham | first5 = AH. | last6 = Delabie | first6 = J. | last7 = Braziel | first7 = RM. | last8 = Geng | first8 = H. | last9 = Iqbal | first9 = J. | title = A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy. | journal = Clin Cancer Res | volume = 15 | issue = 17 | pages = 5494-502 | month = Sep | year = 2009 | doi = 10.1158/1078-0432.CCR-09-0113 | PMID = 19706817 }}</ref>
+{{familytree/start}}
+{{familytree | | | | | | |A11| | | | |A11 =DLBCL }}
+{{familytree | | | | |,|-|-|^|-|-|.| |}}
+{{familytree | | | | B11 | | | | B12 |B11=CD10 -ve|B12=CD10 +ve <br>GC }}
+{{familytree | |,|-|-|^|-|-|.| | | | |}}
+{{familytree | D11 | | | | D12 | | | |D11=BCL6 -ve <br>Non-GC|D12=BCL6 +ve }}
+{{familytree | | | | |,|-|-|^|-|-|.| |}}
+{{familytree | | | | F11 | | | | F12 |F11=MUM1 -ve<br>GC|F12=MUM1 +ve <br>Non-GC }}
+{{familytree/end}}
 ==="UHN panel"===
 *H&E 2 micrometers.