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Difference between revisions of "Neuroendocrine neoplasms"
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Neuroendocrine neoplasms (view source)
Revision as of 14:06, 13 October 2011
, 14:06, 13 October 2011+Carcinoid syndrome
(+carcinoma) |
(+Carcinoid syndrome) |
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=Use of the term ''carcinoid''= | =Use of the term ''carcinoid''= | ||
Use of the term ''carcinoid'' is discouraged.<ref name=pmid18414708>{{Cite journal | last1 = Chetty | first1 = R. | title = Requiem for the term 'carcinoid tumour' in the gastrointestinal tract? | journal = Can J Gastroenterol | volume = 22 | issue = 4 | pages = 357-8 | month = Apr | year = 2008 | doi = | PMID = 18414708 }} | Use of the term ''carcinoid'' is discouraged (in pathology reports).<ref name=pmid18414708>{{Cite journal | last1 = Chetty | first1 = R. | title = Requiem for the term 'carcinoid tumour' in the gastrointestinal tract? | journal = Can J Gastroenterol | volume = 22 | issue = 4 | pages = 357-8 | month = Apr | year = 2008 | doi = | PMID = 18414708 }} | ||
</ref><ref name=pmid15153416>{{Cite journal | last1 = Klöppel | first1 = G. | last2 = Perren | first2 = A. | last3 = Heitz | first3 = PU. | title = The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification. | journal = Ann N Y Acad Sci | volume = 1014 | issue = | pages = 13-27 | month = Apr | year = 2004 | doi = | PMID = 15153416 }} | </ref><ref name=pmid15153416>{{Cite journal | last1 = Klöppel | first1 = G. | last2 = Perren | first2 = A. | last3 = Heitz | first3 = PU. | title = The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification. | journal = Ann N Y Acad Sci | volume = 1014 | issue = | pages = 13-27 | month = Apr | year = 2004 | doi = | PMID = 15153416 }} | ||
</ref><ref name=pmid14513276>{{cite journal |author=Klöppel G |title=[Neuroendocrine tumors of the gastrointestinal tract] |language=German |journal=Pathologe |volume=24 |issue=4 |pages=287–96 |year=2003 |month=July |pmid=14513276 |doi=10.1007/s00292-003-0636-7 |url=}}</ref> | </ref><ref name=pmid14513276>{{cite journal |author=Klöppel G |title=[Neuroendocrine tumors of the gastrointestinal tract] |language=German |journal=Pathologe |volume=24 |issue=4 |pages=287–96 |year=2003 |month=July |pmid=14513276 |doi=10.1007/s00292-003-0636-7 |url=}}</ref> | ||
=Carcinoid syndrome= | |||
Cause: | |||
*Neuroendocrine tumour -> hormone secretion (5-hydroxytryptamine + others).<ref name=pmid19444261>{{Cite journal | last1 = Druce | first1 = M. | last2 = Rockall | first2 = A. | last3 = Grossman | first3 = AB. | title = Fibrosis and carcinoid syndrome: from causation to future therapy. | journal = Nat Rev Endocrinol | volume = 5 | issue = 5 | pages = 276-83 | month = May | year = 2009 | doi = 10.1038/nrendo.2009.51 | PMID = 19444261 }}</ref> | |||
Classic pathologic finding:<ref name=pmid19444261/> | |||
*Fibrosis of cardiac valves (tricuspid and pulmonary). | |||
**Result ''TIPS'' = '''t'''ricuspid '''i'''nsufficiency '''p'''ulmonary '''s'''tenosis. | |||
Clinical features:ref name=pmid19444261/> | |||
*Diarrhea, flushing and wheezing. | |||
=Microscopic - generic= | =Microscopic - generic= | ||