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Difference between revisions of "Liver neoplasms"
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==Small cell dysplasia== | ==Small cell dysplasia== | ||
*Considered a | ===General=== | ||
*Considered a precursor to HCC. | |||
===Microscopy=== | ===Microscopy=== | ||
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==Hepatic adenoma== | ==Hepatic adenoma== | ||
===General=== | |||
*AKA ''hepatocellular adenoma''. | *AKA ''hepatocellular adenoma''. | ||
*Grow under the influence of sex hormones. | *Grow under the influence of sex hormones. | ||
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==Hepatocellular carcinoma== | ==Hepatocellular carcinoma== | ||
===General=== | |||
*Commonly abbreviated ''HCC''. | *Commonly abbreviated ''HCC''. | ||
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*Classically one large mass, may have satellite nodules. | *Classically one large mass, may have satellite nodules. | ||
=== | ===Microscopic=== | ||
Features:<ref>{{Ref GLP|609}}</ref> | Features:<ref>{{Ref GLP|609}}</ref> | ||
*Usually an ''adenocarcinoma'', i.e. gland forming with: | *Usually an ''adenocarcinoma'', i.e. gland forming with: | ||
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===IHC=== | ===IHC=== | ||
Classic IHC pattern:<ref>{{Ref GLP|609}}</ref> | Classic IHC pattern:<ref>{{Ref GLP|609}}</ref> | ||
*CK7 +. | *CK7 +ve. | ||
*CK20 +/-. | *CK20 +/-. | ||
*HepPar-1 -. | *HepPar-1 -ve. | ||
ICC vs. HCC:<ref name=pmid19173916>[Evaluation of immunohistochemical markers for differential diagnosis of hepatocellular carcinoma from intrahepatic cholangiocarcinoma] Dong H, Cong WL, Zhu ZZ, Wang B, Xian ZH, Yu H. Zhonghua Zhong Liu Za Zhi. 2008 Sep;30(9):702-5. Chinese. PMID 19173916.</ref> | ICC vs. HCC:<ref name=pmid19173916>[Evaluation of immunohistochemical markers for differential diagnosis of hepatocellular carcinoma from intrahepatic cholangiocarcinoma] Dong H, Cong WL, Zhu ZZ, Wang B, Xian ZH, Yu H. Zhonghua Zhong Liu Za Zhi. 2008 Sep;30(9):702-5. Chinese. PMID 19173916.</ref> | ||
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*Interhepatic cholangiocarcinoma is an adenocarcinoma - it may look like a metastatic lesion. | *Interhepatic cholangiocarcinoma is an adenocarcinoma - it may look like a metastatic lesion. | ||
Further reading: <ref name=pmid17478344>PMID 17478344.</ref> | |||
===Gross pathology/radiology=== | ===Gross pathology/radiology=== | ||
*Multifocal or solitary. | *Multifocal or solitary. | ||