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Difference between revisions of "Kidney tumours"
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→Chromophobe renal cell carcinoma: more
m (→Chromophobe renal cell carcinoma: more) |
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===Microscopic=== | ===Microscopic=== | ||
====Classic==== | ====Classic==== | ||
Features - classic type:<ref>{{Ref PBoD|1016-7}}</ref><ref name=Ref_GUP293>{{Ref GUP|293}}</ref> | Features - classic type (3 P's [[mnemonic]]):<ref>{{Ref PBoD|1016-7}}</ref><ref name=Ref_GUP293>{{Ref GUP|293}}</ref> | ||
*Pale cytoplasm, with wisps of eosinophilic material; the cells are not completely clear, they have "cobwebs". | *Pale cytoplasm, with wisps of eosinophilic material; the cells are not completely clear, they have "cobwebs". | ||
*Perinuclear clearing, i.e. a pale halo surrounds the nucleus - '''key feature'''. | *Perinuclear clearing, i.e. a pale halo surrounds the nucleus - '''key feature'''. | ||
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*[http://commons.wikimedia.org/wiki/File:Oncocytic_chromophobe_rcc_high_mag.jpg Oncocytic chromophobe RCC (WC)]. | *[http://commons.wikimedia.org/wiki/File:Oncocytic_chromophobe_rcc_high_mag.jpg Oncocytic chromophobe RCC (WC)]. | ||
DDx | ====DDx==== | ||
*May appear similar to [[renal oncocytoma|oncocytoma]] -- particularily the eosinophilic variant. | *May appear similar to [[renal oncocytoma|oncocytoma]] -- particularily the eosinophilic variant. | ||
**IHC may be useful to differentiate (CK7: oncocytoma = cytoplasm +ve, chromophobe = cell membrane +ve). | **IHC may be useful to differentiate (CK7: oncocytoma = cytoplasm +ve, chromophobe = cell membrane +ve). | ||
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**Perinuclear clearing is ''not'' seen in clear cell RCC. | **Perinuclear clearing is ''not'' seen in clear cell RCC. | ||
**ChRCC has wisps in the cytoplasm. | **ChRCC has wisps in the cytoplasm. | ||
===IHC=== | |||
*CK7 +ve cell membrane.<ref name=Ref_GUP293>{{Ref GUP|293}}</ref> | |||
*Hale's colloidal iron +ve (cytoplasmic). | |||
===Molecular=== | |||
*Extensive aneusomy (monosomy?):<ref name=Ref_WMSP292>{{Ref WMSP|292}}</ref> | |||
**Loss of chromosomes: 1, 2, 6, 10, 13, 17, 21. | |||
=Renal translocation carcinomas= | =Renal translocation carcinomas= | ||