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Difference between revisions of "Kidney tumours"
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PBoD
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===Subtypes=== | ===Subtypes=== | ||
RCC (renal cell carcinoma) comes in different subtypes:<ref>PBoD | RCC (renal cell carcinoma) comes in different subtypes:<ref name=Ref_PBoD1016>{{Ref PBoD|1016}}</ref> | ||
*Clear cell carcinoma (70-80% of RCC) -- abbrev. CCRCC, | *Clear cell carcinoma (70-80% of RCC) -- abbrev. CCRCC, | ||
*Papillary renal cell carcinoma (10-15% of RCC) -- abbrev. PRCC, | *Papillary renal cell carcinoma (10-15% of RCC) -- abbrev. PRCC, | ||
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==Hereditary RCC== | ==Hereditary RCC== | ||
The classics - which are ''all'' autosomal dominant:<ref>PBoD | The classics - which are ''all'' autosomal dominant:<ref name=Ref_PBoD1016>{{Ref PBoD|1016}}</ref> | ||
# [[Von Hippel-Lindau syndrome]] (clear cell tumours). | # [[Von Hippel-Lindau syndrome]] (clear cell tumours). | ||
# Hereditary clear cell carcinoma (VHL gene). | # Hereditary clear cell carcinoma (VHL gene). | ||
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===Microscopic=== | ===Microscopic=== | ||
Features:<ref>PBoD | Features:<ref>{{Ref PBoD|1017-8}}</ref> | ||
*Clear cells. | *Clear cells. | ||
*Solid or trabecular pattern. | *Solid or trabecular pattern. | ||
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===Epidemiology=== | ===Epidemiology=== | ||
*Associated with ''dialysis associated cystic disease''.<ref>PBoD | *Associated with ''dialysis associated cystic disease''.<ref>{{Ref PBoD|1017-8}}</ref> | ||
===Microsopy=== | ===Microsopy=== | ||
Features:<ref>{{Ref PBoD|1017-8}}</ref> | |||
*Cuboidal or low columnar cell in papillae. | *Cuboidal or low columnar cell in papillae. | ||
*Interstitial foam cells in vascular cores - '''key feature'''.<ref>ALS Feb 9, 2009.</ref> | *Interstitial foam cells in vascular cores - '''key feature'''.<ref>ALS Feb 9, 2009.</ref> | ||
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===Microscopy=== | ===Microscopy=== | ||
Classic Histo.<ref>PBoD | Classic Histo.<ref>{{Ref PBoD|1016-7}}</ref><ref name=Ref_GUP293>{{Ref GUP|293}}</ref>, 3 P's [[mnemonic]]: | ||
*Pale cytoplasm, with wisps of eosinophilic material; the cells are not completely clear, they have "cobwebs". | *Pale cytoplasm, with wisps of eosinophilic material; the cells are not completely clear, they have "cobwebs". | ||
*Perinuclear clearing, i.e. a pale halo surrounds the nucleus - '''key feature'''. | *Perinuclear clearing, i.e. a pale halo surrounds the nucleus - '''key feature'''. | ||
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*High grade nuclear features (nuclear pleomorphism). | *High grade nuclear features (nuclear pleomorphism). | ||
*High mitotic rate. | *High mitotic rate. | ||
*[[Hobnail pattern]] - cell width smaller at basement membrane than free surface ??? <ref>PBoD | *[[Hobnail pattern]] - cell width smaller at basement membrane than free surface ??? <ref>{{Ref PBoD|1018}}</ref> | ||
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*Spindle cells. | *Spindle cells. | ||
=See also= | |||
*[[Urinary bladder]]. | *[[Urinary bladder]]. | ||
*[[Medical kidney]]. | *[[Medical kidney]]. | ||
=References= | |||
{{reflist|2}} | {{reflist|2}} | ||
[[Category: Genitourinary pathology]] | [[Category: Genitourinary pathology]] | ||