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Difference between revisions of "Pancreas"
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GLP, PBoD
(re-order, tighten-up) |
(GLP, PBoD) |
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===Microscopic=== | ===Microscopic=== | ||
====Mucinous cystadenoma==== | ====Mucinous cystadenoma==== | ||
Features:<ref>GLP | Features:<ref name=Ref_GLP489>{{Ref GLP|489}}</ref> | ||
*Simple tall columnar epithelium with large mucin vacuole on apical aspect. | *Simple tall columnar epithelium with large mucin vacuole on apical aspect. | ||
*"Ovarian-type stroma" under epithelium. | *"Ovarian-type stroma" under epithelium. | ||
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===Epidemiology=== | ===Epidemiology=== | ||
Features:<ref>GLP | Features:<ref name=Ref_GLP493>{{Ref GLP|493}}</ref> | ||
*Usually females (M:F=1:9). | *Usually females (M:F=1:9). | ||
*Mean age of presentation third decade (20s). | *Mean age of presentation third decade (20s). | ||
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===Microscopic=== | ===Microscopic=== | ||
Features:<ref>GLP | Features:<ref>{{Ref GLP|493-5}}</ref> | ||
*Solid sheets of cells, focally dyscohesive. | *Solid sheets of cells, focally dyscohesive. | ||
*Eosinophilic cytoplasm. | *Eosinophilic cytoplasm. | ||
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==Pancreatic intraepithelial neoplasia (PanIN)== | ==Pancreatic intraepithelial neoplasia (PanIN)== | ||
*PanIN is thought to be the precursor lesion for pancreatic carcinoma.<ref>PBoD | *PanIN is thought to be the precursor lesion for pancreatic carcinoma.<ref name=Ref_PBoD949>{{Ref PBoD|949}}</ref> | ||
===Overview=== | ===Overview=== | ||
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===Histomorphology=== | ===Histomorphology=== | ||
Features:<ref>PBoD | Features:<ref name=Ref_PBoD949>{{Ref PBoD|949}}</ref> | ||
*PanIN1a - increased amount of cytoplasm. | *PanIN1a - increased amount of cytoplasm. | ||
**Nuclear size & stratification perserved, arch. perserved. | **Nuclear size & stratification perserved, arch. perserved. | ||
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===General=== | ===General=== | ||
*Usually in the head ~60%. | *Usually in the head ~60%. | ||
**15% in the body, 5% tail, 20% diffuse (head, body & tail).<ref>PBoD | **15% in the body, 5% tail, 20% diffuse (head, body & tail).<ref name=Ref_PBoD950>{{Ref PBoD|950}}</ref> | ||
*Abysmal prognosis. | *Abysmal prognosis. | ||
===Microscopic=== | ===Microscopic=== | ||
Features:<ref>PBoD | Features:<ref name=Ref_PBoD951>{{Ref PBoD|951}}</ref> | ||
*Often glandular, may be solid. | *Often glandular, may be solid. | ||
*Nuclei. | *Nuclei. | ||