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Difference between revisions of "Prostate gland"
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==HGPIN (high grade prostatic intraepithelial neoplasia)== | ==HGPIN (high grade prostatic intraepithelial neoplasia)== | ||
===General=== | |||
*Thought to be a precursor lesion for prostate adenocarcinoma. | |||
===Microscopy=== | |||
*Diagnosed on basis of nuclear changes. | *Diagnosed on basis of nuclear changes. | ||
**Hyperchromatic nuclei. | **Hyperchromatic nuclei. | ||
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Note: Low grade PIN (LGPIN) is ''never'' diagnosed. It was found to be a useless diagnosis with no significant prognostic significance. | Note: Low grade PIN (LGPIN) is ''never'' diagnosed. It was found to be a useless diagnosis with no significant prognostic significance. | ||
===HGPIN architecture=== | ====HGPIN architecture==== | ||
There are several forms:<ref>WMSP P.380.</ref><ref name=pmid14739906>{{Cite journal | last1 = Bostwick | first1 = DG. | last2 = Qian | first2 = J. | title = High-grade prostatic intraepithelial neoplasia. | journal = Mod Pathol | volume = 17 | issue = 3 | pages = 360-79 | month = Mar | year = 2004 | doi = 10.1038/modpathol.3800053 | PMID = 14739906 | url=http://www.nature.com/modpathol/journal/v17/n3/pdf/3800053a.pdf }}</ref> | There are several forms:<ref>WMSP P.380.</ref><ref name=pmid14739906>{{Cite journal | last1 = Bostwick | first1 = DG. | last2 = Qian | first2 = J. | title = High-grade prostatic intraepithelial neoplasia. | journal = Mod Pathol | volume = 17 | issue = 3 | pages = 360-79 | month = Mar | year = 2004 | doi = 10.1038/modpathol.3800053 | PMID = 14739906 | url=http://www.nature.com/modpathol/journal/v17/n3/pdf/3800053a.pdf }}</ref> | ||
*Flat. | *Flat - uncommon. | ||
*Tufting. | *Tufting - common. | ||
*Micropapillary - common. | *Micropapillary - common. | ||
*Cribriform - rare. | *Cribriform - rare. | ||
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IHC patterns: | IHC patterns: | ||
*Cancer: AMACR+, p63-, HMWCK-. | *Cancer: AMACR +ve, p63 -ve, HMWCK -ve. | ||
*HGPIN: AMACR+, p63+, HMWCK+. | *HGPIN: AMACR +ve, p63 +ve, HMWCK +ve. | ||
*Normal: AMACR-, p63+, HMWCK+. | *Normal: AMACR -ve, p63 +ve, HMWCK ve+. | ||
==Atrophy== | ==Atrophy== | ||