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Difference between revisions of "Lymph node pathology"
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==Castleman disease== | ==Castleman disease== | ||
===General=== | ===General=== | ||
*Benign. ( | *[[AKA]] ''angiofollicular lymph node hyperplasia'', ''giant lymph node hyperplasia''.<ref>URL: [http://www.mayoclinic.com/health/castleman-disease/DS01000 http://www.mayoclinic.com/health/castleman-disease/DS01000]. Accessed on: 17 June 2010.</ref> | ||
*Benign. | |||
*Abbreviated '''CD'''. | |||
===Classification=== | |||
CD is grouped by location/involvment: | |||
*Hyaline vascular variant. | |||
**Usually unicentric. | |||
**Typically mediastinal or axial. | |||
*Plasma cell variant. | |||
**Usually multicentric. | |||
**Abundant plasma cells. | |||
**Associated with HHV-8 infection (the same virus implicated in ''Kaposi's sarcoma''). | |||
Discussed here: <ref name=pmid19546611>PMID 19546611</ref> | |||
===Microscopic=== | ===Microscopic=== | ||
Features:<ref>URL: [http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html]. Accessed on: 15 June 2010.</ref> | Features:<ref>URL: [http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html]. Accessed on: 15 June 2010.</ref> | ||
*Pale concentric mantle zone lymphocytes. | *Pale concentric (expanded) mantle zone lymphocytes. | ||
**"Regressed follicle". (???) | |||
*"Lollipops" - germinal centers fed by prominent vessels; lollipop-like appearance. | *"Lollipops" - germinal centers fed by prominent vessels; lollipop-like appearance. | ||
*Two germinal centers in one follicle. | *Two germinal centers in one follicle. | ||