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Difference between revisions of "Soft tissue lesions"
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→Tumours of uncertain differentiation: more
(→Pleomorphic undifferentiated sarcoma: tweak -- relation to AFX) |
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| Line 283: | Line 283: | ||
=Tumours of uncertain differentiation= | =Tumours of uncertain differentiation= | ||
==Angiomatoid fibrous histiocytoma== | |||
===General=== | |||
*Rarely metastasizes. | |||
*Children & young adults. | |||
===Microscopic=== | |||
Features:<ref name=Ref_WMSP624-5>{{Ref WMSP|624-5}}</ref> | |||
*Cysts with blood. | |||
*Epithelioid to spindle cells. | |||
*Inflammation. | |||
*Hemorrhage. | |||
===IHC=== | |||
Features:<ref name=Ref_WMSP624-5>{{Ref WMSP|624-5}}</ref> | |||
*CD68 +ve. | |||
*CD57 +ve. | |||
*Desmin +ve. | |||
*Vimentin +ve. | |||
===Molecular=== | |||
AFH has recurrent [[translocations]]: | |||
*t(12;16) FUS/ATF1. | |||
*t(12;22) EWS/ATF1. | |||
==Aggressive angiomyxoma== | ==Aggressive angiomyxoma== | ||
*[[AKA]] deep aggressive angiomyxoma. | *[[AKA]] deep aggressive angiomyxoma. | ||