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Difference between revisions of "Melanocytic lesions"
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→Benign lesions: chg table type, wikify
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===Benign lesions=== | ===Benign lesions=== | ||
{| class="wikitable" | {| class="wikitable sortable" style="margin-left:auto;margin-right:auto" | ||
| '''Name''' | | '''Name''' | ||
| '''Key feature''' | | '''Key feature''' | ||
| Line 16: | Line 16: | ||
| '''Ref.''' | | '''Ref.''' | ||
|- | |- | ||
| Lentigo simplex | | [[Lentigo simplex]] | ||
| no nests, epidermis only | | no nests, epidermis only | ||
| slender rete with melanocytes; no nests of melanocytes; no dermal melanocytes | | slender rete with melanocytes; no nests of melanocytes; no dermal melanocytes | ||
| Line 24: | Line 24: | ||
| <ref name=Ref_WMSP498>{{Ref WMSP|498}}</ref> | | <ref name=Ref_WMSP498>{{Ref WMSP|498}}</ref> | ||
|- | |- | ||
| Junctional melanocytic nevus | | [[Junctional melanocytic nevus]] | ||
| nests in epidermis | | nests in epidermis | ||
| nests of melanocytes at tips of rete, no dermal melanocytes | | nests of melanocytes at tips of rete, no dermal melanocytes | ||
| Line 32: | Line 32: | ||
| <ref name=Ref_WMSP498>{{Ref WMSP|498}}</ref> | | <ref name=Ref_WMSP498>{{Ref WMSP|498}}</ref> | ||
|- | |- | ||
| Compound melanocytic nevus | | [[Compound melanocytic nevus]] | ||
| benign nests in dermis & epidermis | | benign nests in dermis & epidermis | ||
| nests of melanocytes at tips of rete and in dermis; dermal melanocytes lack nucleoli, lack mitoses and "mature with depth" -- see ''Note 1''. | | nests of melanocytes at tips of rete and in dermis; dermal melanocytes lack nucleoli, lack mitoses and "mature with depth" -- see ''Note 1''. | ||
| Line 40: | Line 40: | ||
| <ref name=Ref_WMSP499>{{Ref WMSP|499}}</ref> | | <ref name=Ref_WMSP499>{{Ref WMSP|499}}</ref> | ||
|- | |- | ||
| Intradermal melanocytic nevus | | [[Intradermal melanocytic nevus]] | ||
| nested & individual melanocytes - only in dermis | | nested & individual melanocytes - only in dermis | ||
| nested & individual melanocytes - only in dermis, +/- multinucleation, +/-pseudovascular spaces | | nested & individual melanocytes - only in dermis, +/- multinucleation, +/-pseudovascular spaces | ||
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| <ref name=Ref_WMSP499>{{Ref WMSP|499}}</ref> | | <ref name=Ref_WMSP499>{{Ref WMSP|499}}</ref> | ||
|- | |- | ||
| Spitz nevus (epithelioid and spindle-cell nevus) | | [[Spitz nevus]] (epithelioid and spindle-cell nevus) | ||
| long axis of nests perpendicular to surface | | long axis of nests perpendicular to surface | ||
| spindled, epithelioid or mixed melanocytes, long axis of nests perpendicular to surface, superficial mitoses common | | spindled, epithelioid or mixed melanocytes, long axis of nests perpendicular to surface, superficial mitoses common | ||
| Line 56: | Line 56: | ||
| <ref name=Ref_WMSP499>{{Ref WMSP|499}}</ref> | | <ref name=Ref_WMSP499>{{Ref WMSP|499}}</ref> | ||
|- | |- | ||
| Pigmented spindle cell nevus of Reed (AKA Pigmented spindle cell nevus) | | [[Pigmented spindle cell nevus]] of Reed (AKA Pigmented spindle cell nevus) | ||
| nests of heavily pigmented spindle cells | | nests of heavily pigmented spindle cells | ||
| heavily pigmented spindle cells in epidermis & dermis, form "basketweave" pattern, nests (???) | | heavily pigmented spindle cells in epidermis & dermis, form "basketweave" pattern, nests (???) | ||
| Line 64: | Line 64: | ||
| <ref name=Ref_WMSP500>{{Ref WMSP|500}}</ref> | | <ref name=Ref_WMSP500>{{Ref WMSP|500}}</ref> | ||
|- | |- | ||
| Blue nevus | | [[Blue nevus]] | ||
| lentil-shaped (ovoid) nests btw collagen bundles | | lentil-shaped (ovoid) nests btw collagen bundles | ||
| dermal lentil-shaped nests, mix of spindle or dendritic or epithelioid cell morphology, nests btw collagen | | dermal lentil-shaped nests, mix of spindle or dendritic or epithelioid cell morphology, nests btw collagen | ||
| Line 72: | Line 72: | ||
| <ref name=Ref_WMSP501>{{Ref WMSP|501}}</ref> | | <ref name=Ref_WMSP501>{{Ref WMSP|501}}</ref> | ||
|- | |- | ||
| Cellular blue nevus | | [[Cellular blue nevus]] | ||
| dermal lesion with pigmented spindle cells & epithelioid cells | | dermal lesion with pigmented spindle cells & epithelioid cells | ||
| deep dermis; cells lack nucleoli; biphasic: (1) epithelioid cells with pale cytoplasm, (2) pigmented spindle cells +/- melanophages | | deep dermis; cells lack nucleoli; biphasic: (1) epithelioid cells with pale cytoplasm, (2) pigmented spindle cells +/- melanophages | ||
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| <ref name=Ref_WMSP501>{{Ref WMSP|501}}</ref> | | <ref name=Ref_WMSP501>{{Ref WMSP|501}}</ref> | ||
|- | |- | ||
| Congenital-pattern | | [[Congenital-pattern nevus]] | ||
| growth along dermal structures | | growth along dermal structures | ||
| extend along dermal structures (e.g. nerves, hair shafts, ducts); lacks atypia; +/-mitoses | | extend along dermal structures (e.g. nerves, hair shafts, ducts); lacks atypia; +/-mitoses | ||
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| <ref name=Ref_WMSP501>{{Ref WMSP|501}}</ref> | | <ref name=Ref_WMSP501>{{Ref WMSP|501}}</ref> | ||
|- | |- | ||
| Dysplastic nevus (Clark's nevus) | | [[Dysplastic nevus]] (Clark's nevus) | ||
| melanocyte bridges, lamellar fibrosis | | melanocyte bridges, lamellar fibrosis | ||
| melanocytes "bridges" btw sides of rete, "lamellar fibrosis" (collagen deep to epidermis), mod. atypia | | melanocytes "bridges" btw sides of rete, "lamellar fibrosis" (collagen deep to epidermis), mod. atypia | ||
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| <ref name=Ref_WMSP502>{{Ref WMSP|502}}</ref> | | <ref name=Ref_WMSP502>{{Ref WMSP|502}}</ref> | ||
|- | |- | ||
| Halo nevus | | [[Halo nevus]] | ||
| lymphocytes +++ | | lymphocytes +++ | ||
| lymphocytes at perimeter of melanocytic; epidermal melanocytes not nested; may be dermal, epidermal or both | | lymphocytes at perimeter of melanocytic; epidermal melanocytes not nested; may be dermal, epidermal or both | ||