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Difference between revisions of "Medical lung diseases"
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=Miscellaneous diseases= | =Miscellaneous diseases= | ||
==Pneumocytoma== | |||
===General=== | |||
*Previously known as ''sclerosing hemangioma''. | |||
*[[AKA]] ''sclerosing hemangioma''. | |||
*Derived from type 2 pneumocyte.<ref name=pmid15138814>{{Cite journal | last1 = Yamazaki | first1 = K. | title = Type-II pneumocyte differentiation in pulmonary sclerosing hemangioma: ultrastructural differentiation and immunohistochemical distribution of lineage-specific transcription factors (TTF-1, HNF-3 alpha, and HNF-3 beta) and surfactant proteins. | journal = Virchows Arch | volume = 445 | issue = 1 | pages = 45-53 | month = Jul | year = 2004 | doi = 10.1007/s00428-004-1023-3 | PMID = 15138814 }}</ref> | |||
*Progesterone-receptor positive stromal cells.<ref name=pmid15731902>{{Cite journal | last1 = Einsfelder | first1 = BM. | last2 = Müller | first2 = KM. | title = ["Pneumocytoma" or "sclerosing hemangioma": histogenetic aspects of a rare tumor of the lung] | journal = Pathologe | volume = 26 | issue = 5 | pages = 367-77 | month = Sep | year = 2005 | doi = 10.1007/s00292-005-0751-8 | PMID = 15731902 }}</ref> | |||
===Epidemiology=== | |||
*Female in 40s.<ref name=pmid19415961>{{Cite journal | last1 = Keylock | first1 = JB. | last2 = Galvin | first2 = JR. | last3 = Franks | first3 = TJ. | title = Sclerosing hemangioma of the lung. | journal = Arch Pathol Lab Med | volume = 133 | issue = 5 | pages = 820-5 | month = May | year = 2009 | doi = | PMID = 19415961 }}</ref> | |||
*Considered benign; excision is curative. | |||
**Rare case reports of metastases. | |||
===Gross=== | |||
*Peripheral, solitary. | |||
*Well-circumscribed. | |||
===Microscopy=== | |||
Features:<ref name=pmid19415961>{{Cite journal | last1 = Keylock | first1 = JB. | last2 = Galvin | first2 = JR. | last3 = Franks | first3 = TJ. | title = Sclerosing hemangioma of the lung. | journal = Arch Pathol Lab Med | volume = 133 | issue = 5 | pages = 820-5 | month = May | year = 2009 | doi = | PMID = 19415961 }}</ref> | |||
*Mixed cell population. | |||
*Variable architecture: | |||
**Papillary. | |||
**Sclerotic. | |||
**Solid. | |||
**Hemorrhagic. | |||
* +/-Granulomas. | |||
DDx:<reF>URL: [http://www.med.muni.cz/biomedjournal/pdf/2004/01/37_42.pdf http://www.med.muni.cz/biomedjournal/pdf/2004/01/37_42.pdf]. Accessed on: 17 June 2010.</ref> | |||
*Papillary adenoma. | |||
*Neuroendocrine tumour (carcinoid). | |||
===IHC=== | |||
Features:<ref name=pmid15138814/> | |||
*TTF-1 +ve. | |||
*HNF-3 alpha +ve. | |||
*HNF-3 beta +ve. | |||
==Lymphangioleiomyomatosis== | ==Lymphangioleiomyomatosis== | ||
===General=== | ===General=== | ||