48,830
edits
Difference between revisions of "Adrenal gland"
Jump to navigation
Jump to search
m
→Pheochromocytoma: more, images
m (→General) |
m (→Pheochromocytoma: more, images) |
||
| Line 165: | Line 165: | ||
===Microscopic=== | ===Microscopic=== | ||
Features:<ref>{{Ref PBoD8|1161}}</ref> | Features:<ref>{{Ref PBoD8|1161}}</ref> | ||
*Usu. polygonal cells, may be spindled. | *Chief cells: | ||
*Arranged in cell nests - "Zellballen" (literally ''cell balls'') - '''key feature'''. | **Usu. polygonal cells, may be spindled. | ||
*Stippled chromatin ([[AKA]] salt and pepper chromatin) - coarsely granular chromatin. | **Arranged in cell nests - "Zellballen" (literally ''cell balls'') - '''key feature'''. | ||
*Granular cytoplasm, often basophilic - '''important'''. | **Stippled chromatin ([[AKA]] salt and pepper chromatin) - coarsely granular chromatin. | ||
**Granular cytoplasm, often basophilic - '''important'''. | |||
*Sustentacular cells (structural support cell). | |||
*Often haemorrhagic - highly vascular. | *Often haemorrhagic - highly vascular. | ||
*+/-Nuclear pleomorphism. | *+/-Nuclear pleomorphism. | ||
| Line 174: | Line 176: | ||
Notes: | Notes: | ||
*The nested architecture (Zellballen) is useful for differentiating from [[ACC]]. | *The nested architecture (Zellballen) is useful for differentiating from [[ACC]]. | ||
*Metastasis sole criteria of malignancy.<ref name=Ref_PCPBoD8_586>{{Ref PCPBoD8|586}}</ref> | |||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Carotid_body_tumour_2_low_mag.jpg Carotid body tumour - low mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Carotid_body_tumour_2_high_mag.jpg Carotid body tumour - high mag. (WC)]. | |||
===IHC=== | ===IHC=== | ||
*Chromogranin +ve. | *Chief cells: | ||
*Synaptophysin +ve. | **Chromogranin A +ve. | ||
*S100 +ve | **Synaptophysin +ve. | ||
*Sustentacular cells: | |||
**S100 +ve. | |||
===[[EM]]=== | ===[[EM]]=== | ||