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Difference between revisions of "Paget disease of the breast"
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Paget disease of the breast (view source)
Revision as of 05:26, 27 August 2011
, 05:26, 27 August 2011split-out EMPD
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Histologically, i.e. under the [[microscope]], the above are essentially identically; however, the associations (and prognosis) are quite different! | Histologically, i.e. under the [[microscope]], the above are essentially identically; however, the associations (and prognosis) are quite different! | ||
==General== | |||
*Cells in the epithelium, i.e. skin, that look like they don't belong. | *Cells in the epithelium, i.e. skin, that look like they don't belong. | ||
*Associated with underlying breast carcinoma.<ref name=emed_pagets>URL: [http://emedicine.medscape.com/article/1101235-diagnosis http://emedicine.medscape.com/article/1101235-diagnosis]</ref> | *Associated with underlying breast carcinoma.<ref name=emed_pagets>URL: [http://emedicine.medscape.com/article/1101235-diagnosis http://emedicine.medscape.com/article/1101235-diagnosis]</ref> | ||
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*Extra-mammary Paget's disease is not assoc. with malignancy. | *Extra-mammary Paget's disease is not assoc. with malignancy. | ||
==Microscopic== | |||
Features:<ref name=emed_pagets/> | Features:<ref name=emed_pagets/> | ||
*Epitheliod morphology (round/ovoid). | *Epitheliod morphology (round/ovoid). | ||
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*[[Nipple adenoma|Nipple (duct) adenoma]] (clinical DDx). | *[[Nipple adenoma|Nipple (duct) adenoma]] (clinical DDx). | ||
==IHC== | |||
Panel:<ref name=emed_pagets/> | Panel:<ref name=emed_pagets/> | ||
*S-100 -ve, HMB-45 -ve (both typically +ve in melanoma). | *S-100 -ve, HMB-45 -ve (both typically +ve in melanoma). | ||
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*CK5/6 -ve.<ref>RS. May 2010.</ref> | *CK5/6 -ve.<ref>RS. May 2010.</ref> | ||
**Usu. +ve in squamous cell carcinoma. | **Usu. +ve in squamous cell carcinoma. | ||
==See also== | ==See also== | ||
*[[Breast]]. | *[[Breast]]. | ||
*[[Invasive breast cancer]]. | *[[Invasive breast cancer]]. | ||
*[[Paget disease]]. | |||
*[[Extramammary Paget disease]]. | |||
==References== | ==References== | ||