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Difference between revisions of "Gestational trophoblastic disease"
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Gestational trophoblastic disease (view source)
Revision as of 15:37, 15 August 2011
, 15:37, 15 August 2011→Entities - intermediate trophoblast: +EPS
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=Entities - intermediate trophoblast= | =Entities - intermediate trophoblast= | ||
==Exaggerated placental site== | |||
*Abbreviated ''EPS''. | |||
===General=== | |||
*Benign. | |||
Definition: | |||
*"Increased number" of implantation-site intermediate trophoblastic cells. | |||
Note: | |||
*Used to go by a terrible old term: ''syncytial endometritis'':<ref name=ouhsc_kfung>URL: [http://moon.ouhsc.edu/kfung/IACP-OLP/TC-Text/TC-01-Supp.pdf http://moon.ouhsc.edu/kfung/IACP-OLP/TC-Text/TC-01-Supp.pdf]. Accessed on: 15 August 2011.</ref> | |||
**Not syncytial -- mostly. | |||
**Not inflammatory. | |||
===Microscopic=== | |||
Features: | |||
*Intermediate trophoblast: | |||
**Abundant cytoplasm. | |||
*Usu. adjacent to: | |||
**Chorionic villi | |||
**Decidua - endometrial stromal cells with a nucleus central, eosinphilic cytoplasm, well-defined cell borders. | |||
*No mitotic activity. | |||
DDx: | |||
*PSTT. | |||
===IHC=== | |||
*MIB1 ~0%. | |||
**Used to differentiate from [[PSTT]]. | |||
==Placental site trophoblastic tumour== | ==Placental site trophoblastic tumour== | ||
*Abbreviated ''PSTT''. | *Abbreviated ''PSTT''. | ||
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EPS vs. PSTT: | EPS vs. PSTT: | ||
*EPS has a low | *EPS has a low MIB1 (Ki-67). | ||
Images: | Images: | ||
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DDx: | DDx: | ||
*Invasive [[squamous cell carcinoma]]. | *Invasive [[squamous cell carcinoma]]. | ||
**Can be sorted-out with IHC (SCC will typically be: p16 +ve, | **Can be sorted-out with IHC (SCC will typically be: p16 +ve, MIB1 +ve). | ||
=See also= | =See also= | ||