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*Benign atypical endometrial changes associated with chorionic tissue.<ref name=pmid11756756>{{Cite journal | last1 = Arias-Stella | first1 = J. | title = The Arias-Stella reaction: facts and fancies four decades after. | journal = Adv Anat Pathol | volume = 9 | issue = 1 | pages = 12-23 | month = Jan | year = 2002 | doi = | PMID = 11756756 }}</ref> | *Benign atypical endometrial changes associated with chorionic tissue.<ref name=pmid11756756>{{Cite journal | last1 = Arias-Stella | first1 = J. | title = The Arias-Stella reaction: facts and fancies four decades after. | journal = Adv Anat Pathol | volume = 9 | issue = 1 | pages = 12-23 | month = Jan | year = 2002 | doi = | PMID = 11756756 }}</ref> | ||
**May be seen in a normal pregnancy, [[hydatidiform mole]]s, others. | **May be seen in a normal pregnancy, [[hydatidiform mole]]s, others. | ||
*Historically it was diagnosed as [[endometrial cancer]]. | |||
===Microscopic=== | ===Microscopic=== | ||
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Notes: | Notes: | ||
*To the novice... the nuclei look really scary, i.e. they look like cancer. | *To the novice... the nuclei look really scary, i.e. they look like cancer. | ||
DDx: | |||
*[[Choriocarcinoma]]. | |||
*[[Herpes simplex virus|Herpetic]] [[endometritis]]. | |||
Images: | Images: | ||
*[http://commons.wikimedia.org/wiki/File:Arias-Stella_reaction_-_low_mag.jpg Arias-Stella reaction - low mag. (WC)]. | *[http://commons.wikimedia.org/wiki/File:Arias-Stella_reaction_-_low_mag.jpg Arias-Stella reaction - low mag. (WC)]. | ||
*[http://commons.wikimedia.org/wiki/File:Arias-Stella_reaction_-_high_mag.jpg Arias-Stella reaction - high mag. (WC)]. | *[http://commons.wikimedia.org/wiki/File:Arias-Stella_reaction_-_high_mag.jpg Arias-Stella reaction - high mag. (WC)]. | ||
====Subtypes==== | |||
There are five subtypes:<ref name=pmid11756756/> | |||
#Minimal atypia. | |||
#Early secretory pattern. | |||
#Secretory or hypersecretory pattern. | |||
#Regenerative, proliferative or nonsecretory pattern. | |||
#Monstrous cell pattern. | |||
==Screening tests== | ==Screening tests== |
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