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Difference between revisions of "Spleen"
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The '''spleen''' is a forgotten organ. | The '''spleen''' is a forgotten organ. | ||
=Normal histology= | |||
*Capsule. | *Capsule. | ||
*Red pulp - [[red blood cells]]. | *Red pulp - [[red blood cells]]. | ||
*White pulp - white blood cells. | *White pulp - white blood cells. | ||
=Splenic enlargement= | |||
*Portal hypertension (e.g. cirrhosis). | *Portal hypertension (e.g. cirrhosis). | ||
*Lymphoma: | *Lymphoma: | ||
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</ref> | </ref> | ||
=Specific disorders= | |||
==Hyaloserositis== | ==Hyaloserositis== | ||
*Properly referred to as ''hyaloserositis of the spleen''. | *Properly referred to as ''hyaloserositis of the spleen''. | ||
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*[http://commons.wikimedia.org/wiki/File:Littoral_cell_angioma_of_the_spleen_-_very_high_mag.jpg LCA - very high mag. (WC)]. | *[http://commons.wikimedia.org/wiki/File:Littoral_cell_angioma_of_the_spleen_-_very_high_mag.jpg LCA - very high mag. (WC)]. | ||
==See also | =Weird stuff= | ||
*Dendritic cell tumours.<ref name=Ref_WMSP_596>{{Ref WMSP|596}}</ref> | |||
**Interdigitating dendritic cell tumour. | |||
**Follicular dendritic cell tumour. | |||
==Follicular dendritic cell tumour== | |||
*[[AKA]] ''follicular dendritic cell sarcoma''. | |||
===General=== | |||
*Very rare. | |||
*Behave like a low-grade sarcoma.<ref name=pmid9606805>{{Cite journal | last1 = Perez-Ordoñez | first1 = B. | last2 = Rosai | first2 = J. | title = Follicular dendritic cell tumor: review of the entity. | journal = Semin Diagn Pathol | volume = 15 | issue = 2 | pages = 144-54 | month = May | year = 1998 | doi = | PMID = 9606805 }}</ref> | |||
*Reported association with [[Castleman disease]] (hyaline-vascular type).<ref name=pmid9606805/> | |||
===Microscopic=== | |||
Features:<ref name=pmid9606805/> | |||
*Oval or spindle-shaped cellular & nuclear morphology. | |||
*Variable architecture (sheets, fascicles, whorles, storiform pattern). | |||
*Nuclei: | |||
**Small nucleoli. | |||
**Clear or dispersed chromatin. | |||
*Multinucleated cells. | |||
*Interspersed small lymphocytes. | |||
*+/-Necrosis. | |||
*+/-Marked nuclear atypia. | |||
*+/-Abundant mitoses. | |||
===IHC=== | |||
Features:<ref name=pmid9606805/> | |||
*CD21 +ve. | |||
*CD35 +ve. | |||
*Ki-M4p +ve | |||
*Ki-FDRC1p +ve. | |||
*Vimentin +ve. | |||
*S-100 +ve/-ve. | |||
*Muscle-specific actin +ve/-ve. | |||
*EMA +ve/-ve. | |||
=See also= | |||
*[[Haematopathology]]. | *[[Haematopathology]]. | ||
*[[Liver pathology]]. | *[[Liver pathology]]. | ||
=References= | |||
{{reflist|2}} | {{reflist|2}} | ||
=External links= | |||
*[http://www.rcsed.ac.uk/journal/vol47_1/47100010.html Atraumatic rupture of the spleen in adults (rcsed.ac.uk)]. | *[http://www.rcsed.ac.uk/journal/vol47_1/47100010.html Atraumatic rupture of the spleen in adults (rcsed.ac.uk)]. | ||
[[Category:Haematopathology]] | [[Category:Haematopathology]] | ||