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Difference between revisions of "Medical liver disease"
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→Steatohepatitis: format, image
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==Steatohepatitis== | ==Steatohepatitis== | ||
===General=== | |||
*''Steatohepatitis'' is a label for a set of histopathologic findings. | *''Steatohepatitis'' is a label for a set of histopathologic findings. | ||
**May arise due to numerous etiologies, e.g. alcoholic steatohepatitis (ASH), non-alcoholic steatohepatitis (NASH). | **May arise due to numerous etiologies, e.g. alcoholic steatohepatitis (ASH), non-alcoholic steatohepatitis (NASH). | ||
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**It may be a pattern seen in drug toxicity, e.g. methotrexate toxicity.<ref>MG. 22 September 2009.</ref> | **It may be a pattern seen in drug toxicity, e.g. methotrexate toxicity.<ref>MG. 22 September 2009.</ref> | ||
=== | ===Microscopic=== | ||
Features: | Features: | ||
*Steatosis (usually macrovesicular) - '''key feature'''. | *Steatosis (usually macrovesicular) - '''key feature'''. | ||
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*+/-''Chicken-wire'' perisinusoidal fibrosis +/- zone III (centrilobular) fibrosis (early). | *+/-''Chicken-wire'' perisinusoidal fibrosis +/- zone III (centrilobular) fibrosis (early). | ||
**Late-stage disease - portal bridging.<ref name=pmid14991537>{{Cite journal | last1 = Gramlich | first1 = T. | last2 = Kleiner | first2 = DE. | last3 = McCullough | first3 = AJ. | last4 = Matteoni | first4 = CA. | last5 = Boparai | first5 = N. | last6 = Younossi | first6 = ZM. | title = Pathologic features associated with fibrosis in nonalcoholic fatty liver disease. | journal = Hum Pathol | volume = 35 | issue = 2 | pages = 196-9 | month = Feb | year = 2004 | doi = | PMID = 14991537 }}</ref> | **Late-stage disease - portal bridging.<ref name=pmid14991537>{{Cite journal | last1 = Gramlich | first1 = T. | last2 = Kleiner | first2 = DE. | last3 = McCullough | first3 = AJ. | last4 = Matteoni | first4 = CA. | last5 = Boparai | first5 = N. | last6 = Younossi | first6 = ZM. | title = Pathologic features associated with fibrosis in nonalcoholic fatty liver disease. | journal = Hum Pathol | volume = 35 | issue = 2 | pages = 196-9 | month = Feb | year = 2004 | doi = | PMID = 14991537 }}</ref> | ||
Image: [http://commons.wikimedia.org/wiki/File:Steatohepatitis_high_mag.jpg Steatohepatitis (WC)]. | |||
===Grading steatohepatitis=== | ===Grading steatohepatitis=== | ||