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Difference between revisions of "Cytopathology"
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*Mixed population of cells: | *Mixed population of cells: | ||
**Epithelial cells. | **Epithelial cells. | ||
***Circular nuclei with well seen | ***Circular nuclei with well seen micro[[nucleoli]] (seen at ~10X objective). | ||
***+/-Nuclear membrane invaginations. | ***+/-Nuclear membrane invaginations. | ||
**Mature Lymphocytes. | **Mature Lymphocytes. | ||
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*Carcinoma (when lymphoid population small). | *Carcinoma (when lymphoid population small). | ||
**Should not have nuclear features of malignancy. | **Should not have nuclear features of malignancy. | ||
***Adenocarcinoma: marked size variation, larger nucleoli. | ***Adenocarcinoma: marked size variation, larger [[nucleoli]]. | ||
***[[Squamous carcinoma]]: often no nucleoli. (???) | ***[[Squamous carcinoma]]: often no nucleoli. (???) | ||
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[[Cholangiocarcinoma]]: | [[Cholangiocarcinoma]]: | ||
*Looks like an adenocarcinoma: | *Looks like an adenocarcinoma: | ||
**Eccentric nuclei, one nucleolus per cell, abundant cytoplasm, nuclear size var. cell-to-cell, irregular nuclear membrane, irregular/uneven chromatin pattern. | **Eccentric nuclei, one [[nucleolus]] per cell, abundant cytoplasm, nuclear size var. cell-to-cell, irregular nuclear membrane, irregular/uneven chromatin pattern. | ||
===Common bile duct=== | ===Common bile duct=== | ||
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#Mixure of epithelioid cells and spindle cells. | #Mixure of epithelioid cells and spindle cells. | ||
#Malignant cells have: | #Malignant cells have: | ||
#*Prominent red nucleolus. | #*Prominent [[red nucleolus]]. | ||
#*Pigmented cytoplasm - '''key feature''' (often not pigmented). | #*Pigmented cytoplasm - '''key feature''' (often not pigmented). | ||
#*Pigment may only be present in macrophages | #*Pigment may only be present in macrophages | ||
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Notes: | Notes: | ||
#Large nucleolus - may | #Large nucleolus - may vaguely resemble adenocarcinoma. | ||
#*Prominent red nucleolus common in: serous carcinoma. | #*Prominent red nucleolus common in: serous carcinoma. | ||
#The classic appearance of melanoma without pigment is closest to adenocarcinoma (which may have red nucleoli, large cells, abundant cytoplasm, occasional binucleation). | #The classic appearance of melanoma without pigment is closest to adenocarcinoma (which may have red nucleoli, large cells, abundant cytoplasm, occasional binucleation). | ||