Difference between revisions of "Medical lung diseases"

Medical lung diseases (view source)

460 bytes added , 04:09, 4 August 2011

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→‎Asthma: mroe, refs

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 ===General===
 *The bread and butter of respirology.
-*Associated with atopy.
+*May be associated with atopy (allergies), medications (e.g. NSAIDs), occupational exposures.<ref name=Ref_PCPBoD8_370>{{Ref PCPBoD8|370}}</ref>
-*Mast cells thought to play an important role.
+====Pathogenesis====
+*T-cell response T<sub>H</sub>2 dominant.
+Sequence:<ref name=Ref_PCPBoD8_370>{{Ref PCPBoD8|370}}</ref>
+*Antigen + mast cell -> IgE --> leukotriene -> bronchospasm, edema, leukocyte recruitment -> airway remodelling.
+===Gross===
+*Lung over-inflation.
+*Mucous plugs.
+*Focal resorption atelectasis,<ref name=Ref_PCPBoD8_363>{{Ref PCPBoD8|363}}</ref> i.e. collapse.
 ===Microscopic===