Difference between revisions of "Chondro-osseous tumours"

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Chondro-osseous tumours (view source)

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*Secondary - arise due to something else (e.g. [[Paget disease of the bone]] (~80% of secondary osteosarcomas),  radiation (~15% of secondary osteosarcomas)).<ref>URL: [http://www.rsna.org/REG/publications/rg/afip/privateM/1997/0017/0005/1205/6.htm http://www.rsna.org/REG/publications/rg/afip/privateM/1997/0017/0005/1205/6.htm]. Accessed on: 8 April 2011.</ref>
*Secondary - arise due to something else (e.g. [[Paget disease of the bone]] (~80% of secondary osteosarcomas),  radiation (~15% of secondary osteosarcomas)).<ref>URL: [http://www.rsna.org/REG/publications/rg/afip/privateM/1997/0017/0005/1205/6.htm http://www.rsna.org/REG/publications/rg/afip/privateM/1997/0017/0005/1205/6.htm]. Accessed on: 8 April 2011.</ref>
*Gnathic - jaw bones; usu. chondroblastic.
*Gnathic - jaw bones; usu. chondroblastic.
==Giant cell tumour of bone==
===General===
Features:<ref name=Ref_WMSP648>{{Ref WMSP|648}}</ref>
*Approximately 5% of primary bone tumours.
*Typical age: 20-45 years.
====Clinical====
*May present with joint pain, immobility.
Note:
*Several types of giant cell tumours exist.
===Microscopic===
Features:<ref name=Ref_Klatt420>{{Ref Klatt|420}}</ref>
*Giant cells with abundant nuclei (usu. >10 in the plane of section).
**Usu. have prominent nucleoli.
*Mononuclear cells and small multinucleated cells with nuclei similar to those in the giant cells - '''key feature'''.
Images:
*[http://commons.wikimedia.org/wiki/File:Giant_cell_tumour_of_bone_-_high_mag.jpg GCT of bone - high mag. (WC)].
*[http://commons.wikimedia.org/wiki/File:Giant_cell_tumour_of_bone_-_low_mag.jpg GCT of bone - low mag. (WC)].
===IHC===
*p63 +ve in scattered mononuclear cells.<ref name=pmid18311114>{{cite journal |author=Dickson BC, Li SQ, Wunder JS, ''et al.'' |title=Giant cell tumor of bone express p63 |journal=Mod. Pathol. |volume=21 |issue=4 |pages=369–75 |year=2008 |month=April |pmid=18311114 |doi=10.1038/modpathol.2008.29 |url=}}</ref>
**This seems to be contradicted by another paper.<ref name=pmid20012988>{{cite journal |author=Alberghini M, Kliskey K, Krenacs T, ''et al.'' |title=Morphological and immunophenotypic features of primary and metastatic giant cell tumour of bone |journal=Virchows Arch. |volume=456 |issue=1 |pages=97–103 |year=2010 |month=January |pmid=20012988 |doi=10.1007/s00428-009-0863-2 |url=}}</ref>


=Other=
=Other=
Line 585: Line 611:
DDx:
DDx:
*[[Giant cell tumour of bone]] and other [[giant cell lesions]].
*[[Giant cell tumour of bone]] and other [[giant cell lesions]].
==Giant cell tumour of bone==
===General===
Features:<ref name=Ref_WMSP648>{{Ref WMSP|648}}</ref>
*Approximately 5% of primary bone tumours.
*Typical age: 20-45 years.
====Clinical====
*May present with joint pain, immobility.
Note:
*Several types of giant cell tumours exist.
===Microscopic===
Features:<ref name=Ref_Klatt420>{{Ref Klatt|420}}</ref>
*Giant cells with abundant nuclei (usu. >10 in the plane of section).
**Usu. have prominent nucleoli.
*Mononuclear cells and small multinucleated cells with nuclei similar to those in the giant cells - '''key feature'''.
Images:
*[http://commons.wikimedia.org/wiki/File:Giant_cell_tumour_of_bone_-_high_mag.jpg GCT of bone - high mag. (WC)].
*[http://commons.wikimedia.org/wiki/File:Giant_cell_tumour_of_bone_-_low_mag.jpg GCT of bone - low mag. (WC)].
===IHC===
*p63 +ve in scattered mononuclear cells.<ref name=pmid18311114>{{cite journal |author=Dickson BC, Li SQ, Wunder JS, ''et al.'' |title=Giant cell tumor of bone express p63 |journal=Mod. Pathol. |volume=21 |issue=4 |pages=369–75 |year=2008 |month=April |pmid=18311114 |doi=10.1038/modpathol.2008.29 |url=}}</ref>
**This seems to be contradicted by another paper.<ref name=pmid20012988>{{cite journal |author=Alberghini M, Kliskey K, Krenacs T, ''et al.'' |title=Morphological and immunophenotypic features of primary and metastatic giant cell tumour of bone |journal=Virchows Arch. |volume=456 |issue=1 |pages=97–103 |year=2010 |month=January |pmid=20012988 |doi=10.1007/s00428-009-0863-2 |url=}}</ref>


=See also=
=See also=
Michael
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