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Difference between revisions of "Medical lung diseases"
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fix dup. eosinophilic granuloma, pulmonary langerhans histiocytosis
(→Hypersensitivity pneumonitis: +LIP) |
(fix dup. eosinophilic granuloma, pulmonary langerhans histiocytosis) |
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Image: [http://www.scielo.br/img/revistas/jbpneu/v34n2/en_a02fig01.jpg LIP (scielo.br)]. | Image: [http://www.scielo.br/img/revistas/jbpneu/v34n2/en_a02fig01.jpg LIP (scielo.br)]. | ||
=Smoking assoc. disease= | =Smoking assoc. disease= | ||
| Line 350: | Line 329: | ||
*RBILD = respiratory bronchiolitis interstitial lung disease. | *RBILD = respiratory bronchiolitis interstitial lung disease. | ||
*DIP = desquamative interstitial pneumonia. | *DIP = desquamative interstitial pneumonia. | ||
*Eosinophilic granuloma (of lung) - AKA pulmonary langerhans cell histiocytosis. | *Eosinophilic granuloma (of lung) - [[AKA]] pulmonary langerhans cell histiocytosis. | ||
All of the above are assoc. with smoking. RBILD & DIP are considered by many to be on a continuum, i.e. RBILD is early DIP. | All of the above are assoc. with smoking. RBILD & DIP are considered by many to be on a continuum, i.e. RBILD is early DIP. | ||
| Line 386: | Line 365: | ||
*Amiodarone toxicity, fibrotic NSIP - may appear similar. | *Amiodarone toxicity, fibrotic NSIP - may appear similar. | ||
== | ==Pulmonary Langerhans cell histiocytosis== | ||
* | ===General=== | ||
*[[AKA]] eosinophilic granuloma of lung. | |||
*Associated with smoking.<ref name=ppp234>PPP P.234.</ref> | |||
*Not assoc. with systemic diseases of Langerhans cells (AKA Hand-Schueller-Christian disease). | |||
Subtypes:<ref name=ppp234/> | |||
*Cellular form. | |||
*Fibrotic form. | |||
One form usually predominates. | |||
===Radiology=== | ===Radiology=== | ||
| Line 393: | Line 381: | ||
===Histology=== | ===Histology=== | ||
Features:<ref>PPP P.237.</ref> | |||
*Cellular peribronchiolar nodules with: | *Cellular peribronchiolar nodules with: | ||
** | **Langerhans cells: | ||
** | ***Pale staining nucleus (H&E) with nuclear infolding - "crumpled tissue paper" appearance. | ||
**Smoker's macrophages (brown pigmented airspace macrophages). | **+/-Smoker's macrophages (brown pigmented airspace macrophages). | ||
**Chronic inflammatory cells (lymphocytes). | **+/-Eosinophilia (may be rare). | ||
**Chronic inflammatory cells (lymphocytes). (???) | |||
===IHC=== | |||
*Langerhans cells: S100+ and CD1a+.<ref>PPP P.237.</ref> | |||
=Miscellaneous diseases= | =Miscellaneous diseases= | ||