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*Subcapsular space - the first place to look for mets. | *Subcapsular space - the first place to look for mets. | ||
*Lymph node metstasis are usually obvious. | *Lymph node metstasis are usually obvious. | ||
*Histiocytes may be difficult to separate from tumour - | *Histiocytes may be difficult to separate from tumour - especially initially. | ||
**Histiocytes usually are in germinal | **Histiocytes (usually) are in germinal centres, i.e. the node architecture helps. | ||
**Malignant cells have to have malignant features, i.e. the NC ratio is abnormal, there is [[nuclear pleomorphism]]. | **Malignant cells, generally, have to have malignant features, i.e. the NC ratio is abnormal, there is [[nuclear pleomorphism]]. | ||
See: ''[[Lymph node]]'' article for a detailed description of cell types in a lymph node. | See: ''[[Lymph node]]'' article for a detailed description of cell types in a lymph node. |
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