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Difference between revisions of "Endometrial carcinoma"
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→Subtypes: type I and type II
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==Subtypes== | ==Subtypes== | ||
They are commonly grouped based on clinicopathologic features:<ref name=pmid21309259>{{Cite journal | last1 = Lim | first1 = D. | last2 = Oliva | first2 = E. | title = Nonendometrioid endometrial carcinomas. | journal = Semin Diagn Pathol | volume = 27 | issue = 4 | pages = 241-60 | month = Nov | year = 2010 | doi = | PMID = 21309259 }}</ref> | |||
#Type I: | |||
#*Histologic types: | |||
#**Endometrioid (most common). | |||
#**Mucinous. | |||
#*Clinical characteristics: premenopausal, estrogen excess. | |||
#Group II: | |||
#*Histologic types: | |||
#**Serous carcinoma. | |||
#**Clear cell carcinoma. | |||
#*Clinical characteristics: postmenopausal, no estrogen excess, poor prognosis. | |||
The most common as a list: | |||
#Endometrioid - '''most common''', patient typically is 55-65 years old and obese. | #Endometrioid - '''most common''', patient typically is 55-65 years old and obese. | ||
#Serous - patients classically older than endometrioid subtype, arise in atrophic endometrium. | #Serous - patients classically older than endometrioid subtype, arise in atrophic endometrium. | ||
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Notes: | Notes: | ||
*Dyskeratosis = abnormal keratinization;<ref>[http://dictionary.reference.com/browse/dyskeratosis http://dictionary.reference.com/browse/dyskeratosis]</ref> classically have intensely eosinophilic cytoplasm +/- nuclear fragmentation ([http://dictionary.reference.com/browse/karyolysis?db=medical&q=karyolysis karyorrhexis]) - see: [http://www.drmihm.com/pictures/Figure%203.jpg several dyskeratotic cells]. | *Dyskeratosis = abnormal keratinization;<ref>[http://dictionary.reference.com/browse/dyskeratosis http://dictionary.reference.com/browse/dyskeratosis]</ref> classically have intensely eosinophilic cytoplasm +/- nuclear fragmentation ([http://dictionary.reference.com/browse/karyolysis?db=medical&q=karyolysis karyorrhexis]) - see: [http://www.drmihm.com/pictures/Figure%203.jpg several dyskeratotic cells]. | ||
[[Media:Example.ogg]] | |||
==Grading (FIGO)== | ==Grading (FIGO)== | ||
*Based on gland formation & adjusted by nuclear pleomorphism:<ref>{{Ref PBoD|1087-8}}</ref><ref>URL: [http://www.pathologyoutlines.com/uterus.html#endometrialcarc http://www.pathologyoutlines.com/uterus.html#endometrialcarc].</ref><ref>URL: [http://www.emedicine.com/med/topic2832.htm http://www.emedicine.com/med/topic2832.htm].</ref><ref name=pmid12496701>{{cite journal |author=Ayhan A, Taskiran C, Yuce K, Kucukali T |title=The prognostic value of nuclear grading and the revised FIGO grading of endometrial adenocarcinoma |journal=Int. J. Gynecol. Pathol. |volume=22 |issue=1 |pages=71–4 |year=2003 |month=January |pmid=12496701 |doi= |url=}}</ref> | *Based on gland formation & adjusted by nuclear pleomorphism:<ref>{{Ref PBoD|1087-8}}</ref><ref>URL: [http://www.pathologyoutlines.com/uterus.html#endometrialcarc http://www.pathologyoutlines.com/uterus.html#endometrialcarc].</ref><ref>URL: [http://www.emedicine.com/med/topic2832.htm http://www.emedicine.com/med/topic2832.htm].</ref><ref name=pmid12496701>{{cite journal |author=Ayhan A, Taskiran C, Yuce K, Kucukali T |title=The prognostic value of nuclear grading and the revised FIGO grading of endometrial adenocarcinoma |journal=Int. J. Gynecol. Pathol. |volume=22 |issue=1 |pages=71–4 |year=2003 |month=January |pmid=12496701 |doi= |url=}}</ref> | ||