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Difference between revisions of "Prostate gland"
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==Normal== | ==Normal== | ||
===Prostate=== | |||
*Glands have two cell layers (similar to glands in breast). | *Glands have two cell layers (similar to glands in breast). | ||
**Second cell layer may be difficult to see (like in breast). | **Second cell layer may be difficult to see (like in breast). | ||
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**Very important - helps on differentiate from Gleason pattern 3. | **Very important - helps on differentiate from Gleason pattern 3. | ||
*Luminal epithelium often clear. | *Luminal epithelium often clear. | ||
*Single nucleus. | |||
Negatives: | |||
*No nucleoli present (if you see nuclei think: cancer, HGPIN, reactive changes, basal cell hyperplasia). | *No nucleoli present (if you see nuclei think: cancer, HGPIN, reactive changes, basal cell hyperplasia). | ||
*No mitoses - these are uncommon... even in high grade prostate cancer. | *No mitoses - these are uncommon... even in high grade prostate cancer. | ||
Benign normal: | |||
*Corpora amylacea. | *Corpora amylacea. | ||
**Round/ovoid-eosinophilic bodies -- with laminations (layered appearance). | **Round/ovoid-eosinophilic bodies -- with laminations (layered appearance). | ||
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**These should be differentiated from ''eosinophilic proteinaceous debris'' - which is associated with cancer. | **These should be differentiated from ''eosinophilic proteinaceous debris'' - which is associated with cancer. | ||
Male accessory glands: | |||
*Mucinous glands at the apex of the prostate = ''Cowper's gland'' (AKA ''bulbourethral gland''), resemble (mucinous) [[salivary gland]]s.<ref>PR. September 2009.</ref> | *Mucinous glands at the apex of the prostate = ''Cowper's gland'' (AKA ''bulbourethral gland''), resemble (mucinous) [[salivary gland]]s.<ref>PR. September 2009.</ref> | ||
===IHC=== | ====IHC of normal prostate==== | ||
Normal prostate: | Normal prostate: | ||
AMACR-, p63+, HMWCK+, PSA+, PSAP+. | *AMACR-, p63+, HMWCK+, PSA+, PSAP+. | ||
===Seminal vesicles=== | |||
*Leaf-like architecture - epithelial component clustered closely, looks like it connects. | |||
*Lipofuscin. | |||
*Nucleoli - common. | |||
Images: | |||
*[http://dspace.udel.edu:8080/dspace/bitstream/19716/2016/1/cmrsvlm3.GIF SV (udel.edu)]. | |||
==Common diagnoses== | ==Common diagnoses== | ||