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Difference between revisions of "Leukemia"
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→AML with recurrent cytogenetic abnormalities: more
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IHC: | IHC: | ||
*CD2+ -- common. | *CD2+ -- common. | ||
====t(15;17)==== | |||
*t(15;17)(q22;q12). | |||
Comes in two flavours. | |||
Microscopic (Hypergranular ''or'' typical APL): | |||
**Bean-shaped nucleus ''or'' bilobed nucleus. | |||
**Buddles of Auer rods - known as "Faggot cells". | |||
Microscopic (Microgranular ''or'' hypogranular APL): | |||
*Bilobed nuclei with nuclear overlap. (???) | |||
*Absence of granules on light microscopy. | |||
IHC: | |||
*CD2+, CD34+/-, CD56+/-. | |||
[[Flow cytometery]]: | |||
*CD34-, HLA-DR-. | |||
*CD33+, CD13+/-, CD117+ (weak), CD56+/-. | |||
Clinical: | |||
*Assoc. with [[DIC]]. | |||
*Treatment: ATRA. | |||
Variants: | |||
*t(11;17) -- ATRA doesn't work. | |||
*t(17;17) -- ATRA doesn't work. | |||
*t(5;17). (???) | |||
====t(9;11)==== | |||
*t(9;11). | |||
Microscopic: | |||
*Monoblastic morphology. (???) | |||
*Myelomonocytic morphology. (???) | |||
Clinical: | |||
*+/-[[DIC]]. | |||
*Usu. children. | |||
IHC: | |||
*CD33+, CD65+, CD4+, HLA-DR+. | |||
*CD34+. (???) | |||
*CD13+. (???) | |||
==See also== | ==See also== | ||