Difference between revisions of "Myelodysplastic syndromes"

Myelodysplastic syndromes (view source)

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 Notes:
-*Other megakaryocyte markers: factor VIII, vWF. (???)
+*Other markers:
+**Factor VIII.
+**vWF.
+*Blasts - the gold standard: histomorphology.
+**Most blasts are CD34 +ve.
+***[[Flow cytometry]] not useful (yet) for MDS -- as CD34 +ve != blast; may change with more multiplexing.
+**CD117 marks some blasts that are CD34 -ve.
+=[[Cytogenetics]]=
+*Important in the Dx and prognostication of MDS; however, only ~50% have a cytogenetic abnormality based on karyotyping.
+Common changes:
+#Isolated del(5q).
+#Isolated del(17p).
+#*Assoc. with pseudo-Pelger-Huet. (???)
+#Monosomy 7.
+#Monosomy 8.
+There is a scoring system for cytogenetic abnormalities ''International Prognostic Scoring System'',<ref name=pmid21594886>{{Cite journal  | last1 = Garcia-Manero | first1 = G. | title = Myelodysplastic syndromes: 2011 update on diagnosis, risk-stratification, and management. | journal = Am J Hematol | volume = 86 | issue = 6 | pages = 490-8 | month = Jun | year = 2011 | doi = 10.1002/ajh.22047 | PMID = 21594886 }}
+</ref> abbreviated ''IPSS'':
+*Higher score = worse outcome.
 =See also=