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Difference between revisions of "Gaucher disease"
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Features:<ref name=webpath>URL: [http://www.webpathology.com/image.asp?case=377&n=3 http://www.webpathology.com/image.asp?case=377&n=3]. Accessed on: 30 November 2010.</ref><ref name=Ref_PCPBoD8_95>{{Ref PCPBoD8|95}}</ref> | Features:<ref name=webpath>URL: [http://www.webpathology.com/image.asp?case=377&n=3 http://www.webpathology.com/image.asp?case=377&n=3]. Accessed on: 30 November 2010.</ref><ref name=Ref_PCPBoD8_95>{{Ref PCPBoD8|95}}</ref> | ||
*Mononuclear phagocytes with abundant eosinophilic cytoplasm with subtle irregular lines (~0.5 micrometers in width). | *Mononuclear phagocytes with abundant eosinophilic cytoplasm with subtle irregular lines (~0.5 micrometers in width). | ||
**Known as "crumpled tissue paper cells". | **Known as "crumpled tissue paper cells" / "crumpled tissue paper cytoplasm."<ref>URL: [http://pathcuric1.swmed.edu/pathdemo/gen1/gen130.htm http://pathcuric1.swmed.edu/pathdemo/gen1/gen130.htm]. Accessed on: 28 May 2011.</ref> | ||
Notes: | |||
*Crumpled tissue paper: [http://www.123rf.com/photo_3430535_three-pieces-of-purple-tissue-paper-ripped-wrinkled-and-torn-isolated-on-a-white-background.html crumpled tissue paper - image (123rf.com)]. | |||
*The textbook case may look crumpled... along with some mind altering drugs. | |||
**The typical case is: | |||
***Abundant macrophages with cytoplasm filled by very small (clear) vacuoles (~0.2-0.4 micrometres). | |||
Images: | Images: | ||
*[http://commons.wikimedia.org/w/index.php?title=File:Gaucher_disease_-_very_high_mag.jpg Gaucher disease - with fine vesicular cytoplasm - very high mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Gaucher_disease_-_high_mag.jpg Gaucher disease - high mag. (WC)]. | |||
*[http://pathcuric1.swmed.edu/pathdemo/gen1/gen130.htm Gaucher disease - bone marrow aspirate (swmed.edu)]. | |||
*[http://www.webpathology.com/image.asp?case=377&n=3 Gaucher disease (webpathology.com)].<ref name=webpath/> | *[http://www.webpathology.com/image.asp?case=377&n=3 Gaucher disease (webpathology.com)].<ref name=webpath/> | ||
*[http://www.neuropathologyweb.org/chapter10/images10/10-GCl.jpg Gaucher disease (neuropathologyweb.org)].<ref>URL: [http://www.neuropathologyweb.org/chapter10/chapter10bLSDs.html http://www.neuropathologyweb.org/chapter10/chapter10bLSDs.html]. Accessed on: 30 November 2010.</ref> | *[http://www.neuropathologyweb.org/chapter10/images10/10-GCl.jpg Gaucher disease (neuropathologyweb.org)].<ref>URL: [http://www.neuropathologyweb.org/chapter10/chapter10bLSDs.html http://www.neuropathologyweb.org/chapter10/chapter10bLSDs.html]. Accessed on: 30 November 2010.</ref> | ||