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Difference between revisions of "Gestational trophoblastic disease"
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Gestational trophoblastic disease (view source)
Revision as of 17:43, 28 May 2011
, 17:43, 28 May 2011another table
(→Hydatidiform moles: tweak) |
(another table) |
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==Hydatidiform moles== | ==Hydatidiform moles== | ||
===General=== | ===General=== | ||
*Significance: increased risk for choriocarcinoma (in complete moles). | |||
*Non-neoplastic proliferation. | *Non-neoplastic proliferation. | ||
Etymology: | Etymology: | ||
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====Types==== | ====Types==== | ||
*Partial mole | *Partial mole - see [[partial mole]]. | ||
*Complete mole - see [[complete mole]]. | |||
*Complete mole | |||
===Microscopic=== | ===Microscopic=== | ||
==== | ====Mole vs. normal==== | ||
*Moles have large [[chorionic villi]] with edema and abnormal blood vessels.<ref>URL: [http://pathologyoutlines.com/placenta.html#hydatgeneral http://pathologyoutlines.com/placenta.html#hydatgeneral].</ref> | |||
= | Hydropic changes: | ||
{| class="wikitable" | |||
| '''Entity''' | |||
| '''Villi (outline)''' | |||
| '''Blood vessels''' | |||
| '''Nucleated RBCs''' | |||
| '''p57 staining''' | |||
| '''Ploidy''' | |||
| '''Image''' | |||
|- | |||
| Complete mole | |||
| bizarre | |||
| canalicular (thin walled) / few (???) | |||
| rare | |||
| -ve | |||
| diploid / tetraploid | |||
| ? | |||
|- | |||
| Partial mole | |||
| jagged | |||
| present | |||
| common | |||
| +ve | |||
| triploid | |||
| ? | |||
|- | |||
| Hydropic abortus | |||
| smooth | |||
| common | |||
| common | |||
| +ve | |||
| diploid | |||
| ? | |||
|} | |||
===IHC=== | ===IHC=== | ||
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*Formal name: ''partial hydatidiform mole''. | *Formal name: ''partial hydatidiform mole''. | ||
=== | ===General=== | ||
Genetics: | |||
*Polypoid - usually triploid (e.g. 69XXY). | *Polypoid - usually triploid (e.g. 69XXY). | ||
Images: [http://www.gfmer.ch/selected_images_v2/detail_list.php?cat1=12&cat2=86&cat3=795&cat4=3&stype=n] | Images: [http://www.gfmer.ch/selected_images_v2/detail_list.php?cat1=12&cat2=86&cat3=795&cat4=3&stype=n] | ||
=== | ===Microscopic=== | ||
Features: | |||
*Abnormal chorionic villi. | *Abnormal chorionic villi. | ||
**Villi too large (>0.1 mm ?). | **Villi too large (>0.1 mm ?). | ||
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*Also known as ''classic mole''. | *Also known as ''classic mole''. | ||
=== | ===General=== | ||
*May precede [[choriocarcinoma]] | Epidemiology: | ||
*May precede [[choriocarcinoma]]<ref name=Ref_PBoD1111>{{Ref PBoD|1111}}</ref> ~ 1-2% risk. | |||
Genetics: | |||
*Diploid - most are 46XX. | *Diploid - most are 46XX. | ||
* | *Male derived, i.e. arise from DNA in sperm; empty egg fertilized. | ||
=== | ===Radiology=== | ||
*"Snowstorm" appearance on ultrasound.<ref>URL:[http://www.jultrasoundmed.org/cgi/content/abstract/18/9/589 http://www.jultrasoundmed.org/cgi/content/abstract/18/9/589]. Accessed on: 27 July 2010.</ref> | |||
===Microscopic=== | |||
Features: | |||
*No normal villi. | *No normal villi. | ||
*No fetal parts seen. | *No fetal parts seen. | ||
**Very rarely nucleated [[RBC]]s. | |||
Image: | Image: | ||
*[http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70167-X Complete mole (pathconsultddx.com)]. | *[http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70167-X Complete mole (pathconsultddx.com)]. | ||
==Placental site trophoblastic tumour== | ==Placental site trophoblastic tumour== | ||