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Difference between revisions of "Gestational trophoblastic disease"
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Gestational trophoblastic disease (view source)
Revision as of 17:22, 28 May 2011
, 17:22, 28 May 2011→Hydatidiform moles: more
(→Hydatidiform moles: more) |
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==Hydatidiform moles== | ==Hydatidiform moles== | ||
===Types=== | ===General=== | ||
*Non-neoplastic proliferation. | |||
*Significance: increased risk for choriocarcinoma (in complete moles). | |||
Etymology: | |||
*''Hydatid'' is literally ''watery vesicle''.<ref>URL: [http://dictionary.reference.com/browse/hydatid http://dictionary.reference.com/browse/hydatid].</ref> | |||
====Types==== | |||
*Partial mole. | *Partial mole. | ||
**Triploid. | |||
**Choriocarcinoma extremely rare. | |||
*Complete mole. | *Complete mole. | ||
**Diploid or tetraploid. | |||
**"Empty" egg fertilized, ergo paternal DNA. | |||
**Risk for choriocarcinoma; memory device '''c'''omplete -> '''c'''horiocarcinoma. | |||
===Mole vs. normal=== | ===Microscopic=== | ||
====Partial==== | |||
Features: | |||
*Usu. small. | |||
*Fibrotic | |||
*Scant trophoblastic proliferation. | |||
*Nucleated RBCs common. | |||
====Complete==== | |||
Features: | |||
*Canalicular (thin) blood vessels. | |||
*Cisterns usu. well-developed. | |||
**Large empty areas within trophoblastic tissue. | |||
*Rarely nucleated [[RBC]]s. | |||
====Mole vs. normal==== | |||
*Moles have large [[chorionic villi]] with edema and abnormal blood vessels.<ref>URL: [http://pathologyoutlines.com/placenta.html#hydatgeneral http://pathologyoutlines.com/placenta.html#hydatgeneral].</ref> | *Moles have large [[chorionic villi]] with edema and abnormal blood vessels.<ref>URL: [http://pathologyoutlines.com/placenta.html#hydatgeneral http://pathologyoutlines.com/placenta.html#hydatgeneral].</ref> | ||
===IHC=== | ===IHC=== | ||
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***'''3 Ps''' - partial moles are triploid. | ***'''3 Ps''' - partial moles are triploid. | ||
=== | ===Molecular=== | ||
*The type of mole can be determined by cytogenetics.<ref>[http://jcp.bmjjournals.com/cgi/reprint/51/6/438.pdf http://jcp.bmjjournals.com/cgi/reprint/51/6/438.pdf]</ref> | *The type of mole can be determined by [[cytogenetics]].<ref>[http://jcp.bmjjournals.com/cgi/reprint/51/6/438.pdf http://jcp.bmjjournals.com/cgi/reprint/51/6/438.pdf]</ref> | ||
==Partial Mole== | ==Partial Mole== | ||