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Difference between revisions of "Lymphoma"
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→Plasmacytoma: +IHC, +molecular
(→B cell lymphomas: wikify) |
(→Plasmacytoma: +IHC, +molecular) |
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| Line 308: | Line 308: | ||
DDx: | DDx: | ||
*Neuroendocrine carcinoma - nucleus often has a plasmacytoid (plasma cell-like) appearance. | *Neuroendocrine carcinoma - nucleus often has a plasmacytoid (plasma cell-like) appearance. | ||
===IHC=== | |||
*Kappa -- usu. slightly stronger than lambda. | |||
*Lambda. | |||
*CD56.<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/116930 http://www.ncbi.nlm.nih.gov/omim/116930]. Accessed on: 31 August 2010.</ref> | |||
**Also +ve in NK/T cell lymphomas. | |||
*CD57. | |||
**Also +ve in T-cell large granular lymphocytic leukemia.<ref>URL: [http://www.nature.com/bmt/journal/v33/n1/full/1704298a.html http://www.nature.com/bmt/journal/v33/n1/full/1704298a.html]. Accessed on: 31 August 2010.</ref>. | |||
*CD138. | |||
*CD38. (???) | |||
===Molecular=== | |||
*t(4;14)(p16.3;q32.3) / IGH–MMSET.<ref name=pmid9787135>{{Cite journal | last1 = Chesi | first1 = M. | last2 = Nardini | first2 = E. | last3 = Lim | first3 = RS. | last4 = Smith | first4 = KD. | last5 = Kuehl | first5 = WM. | last6 = Bergsagel | first6 = PL. | title = The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts. | journal = Blood | volume = 92 | issue = 9 | pages = 3025-34 | month = Nov | year = 1998 | doi = | PMID = 9787135 }}</ref> | |||
**Assoc. with poor prognosis.<ref name=pmid12393535>{{Cite journal | last1 = Keats | first1 = JJ. | last2 = Reiman | first2 = T. | last3 = Maxwell | first3 = CA. | last4 = Taylor | first4 = BJ. | last5 = Larratt | first5 = LM. | last6 = Mant | first6 = MJ. | last7 = Belch | first7 = AR. | last8 = Pilarski | first8 = LM. | title = In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression. | journal = Blood | volume = 101 | issue = 4 | pages = 1520-9 | month = Feb | year = 2003 | doi = 10.1182/blood-2002-06-1675 | PMID = 12393535 }}</ref> | |||
==Acute myeloid leukemia== | ==Acute myeloid leukemia== | ||