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Difference between revisions of "Molecular pathology"
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| PCR + sequencing ''or'' enzyme digestion and electrophoresis | | PCR + sequencing ''or'' enzyme digestion and electrophoresis | ||
| high resolution (can find very small changes, e.g. base pair substitutions); can be done on formalin fixed | | high resolution (can find very small changes, e.g. base pair substitutions); can be done on [[formalin]] fixed paraffin embedded tissue | ||
| expensive; thus, limited to small regions; sequencing is the gold standard but very costly; enzyme digestion and electrophoresis is a compromise of sorts where one needs to know something about the expected abnormality | | expensive; thus, limited to small regions; sequencing is the gold standard but very costly; enzyme digestion and electrophoresis is a compromise of sorts where one needs to know something about the expected abnormality | ||
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