Difference between revisions of "Molecular pathology tests"

Molecular pathology tests (view source)

818 bytes added , 14:37, 17 May 2011

m

48,860

edits

@@ Line 75: / Line 75: @@
 ===Leukemia===
-BCR-ABL - used to detect residual disease.<ref>{{Ref PCPBoD8|175}}</ref>
+Tests for leukemias:<ref name=uhn_molecular_tests>University Health Network. Molecular diagnostics - current testing. Document number: PMD10002. Version 2.0. March 30, 2011.</ref>
+{| class="wikitable sortable" style="margin-left:auto;margin-right:auto"
+! Target
+! Technique
+! Disease
+! Notes
+|-
+| BCR-ABL1 t(9;22)
+| RQ-PCR
+| CML, ALL
+| used to detect residual disease<ref>{{Ref PCPBoD8|175}}</ref>
+|-
+| MLL-AF4 t(4;11)
+| RQ-PCR
+|
+|
+|-
+| PML-RARA t(15;17)
+| RQ-PCR
+| APL
+| detect relapse, diagnostic, determines therapy
+|-
+| RUNX1-RUNX1T1 (AKA AML1/ETO) t(8;21)
+| RQ-PCR
+| AML-M2
+| good prognosis
+|-
+| CBFB-MYHII t(16;16)
+| RQ-PCR
+| AML-M4Eo
+| good prognosis
+|-
+| ETV6-RUNX1 t(12;21)
+| RQ-PCR
+| ALL, AML
+| good prognosis
+|-
+| FLT3, NPM1 (FLT-3, NPM)
+| RT-PCR/RE digest
+| AML
+| prognostic
+|-
+| 15 STR loci, amelogenin
+| PCR
+| chimerism (post BMT), identity testing
+| monitor transplants
+|}
 ===Carcinoma===