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Difference between revisions of "Adrenal cortical adenoma"
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*[[Cushing disease]] is due to the ACTH over-production by the [[pituitary]]. | *[[Cushing disease]] is due to the ACTH over-production by the [[pituitary]]. | ||
*In cortisol producing tumours (''Cushing syndrome''): atrophy of the non-hyperplastic cortex (due to feedback inhibition from the [[pituitary gland]]). | *In cortisol producing tumours (''Cushing syndrome''): atrophy of the non-hyperplastic cortex (due to feedback inhibition from the [[pituitary gland]]). | ||
===Serology and genes=== | |||
The serology in adenoma has been associated with certain genes:<ref name=pmid30969728>{{cite journal |authors=Mahmood E, Loughner CL, Anastasopoulou C |title= |journal= |volume= |issue= |pages= |date= |pmid=30969728 |doi= |url=}}</ref> | |||
{| class="wikitable sortable" | |||
|serology | |||
|gene(s) | |||
|- | |||
|non-secreting adenoma | |||
|CTNNB1 | |||
|- | |||
|cortisol-producing | |||
|PRKACA, GNAS1, MENIN, ARMC5, APC, FH, PRKAR1A, PDE11A, PDE8B | |||
|- | |||
|aldosterone-producing | |||
|KCNJ5, ATP1A1, ATP2B3, CACNA1D, CTNNB1 | |||
|} | |||
Note: | |||
*Androgen producing adenomas are rare; androgen production more common in [[adrenal cortical carcinoma]].<ref name=pmid30969728> | |||
==Microscopic== | ==Microscopic== | ||