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Etiology: | Etiology: | ||
*Associated with [[EBV]],<ref name=pmid17347662/> | *Associated with [[EBV]],<ref name=pmid17347662/> in most anatomical sites (nasopharynx, stomach, lung, thymus, salivary gland); the skin and [[uterine cervix]] appear to be exceptions.<ref name=pmid7726142>{{Cite journal | last1 = Lespagnard | first1 = L. | last2 = Cochaux | first2 = P. | last3 = Larsimont | first3 = D. | last4 = Degeyter | first4 = M. | last5 = Velu | first5 = T. | last6 = Heimann | first6 = R. | title = Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction. | journal = Am J Clin Pathol | volume = 103 | issue = 4 | pages = 449-52 | month = Apr | year = 1995 | doi = | PMID = 7726142 }}</ref> | ||
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*The (macroscopic, microscopic, epidemiologic, prognostic)) features of LELC are very similar to ''medullary carcinoma'' -- EBV status is one differentiator.<ref name=pmid7726142>{{Cite journal | last1 = Lespagnard | first1 = L. | last2 = Cochaux | first2 = P. | last3 = Larsimont | first3 = D. | last4 = Degeyter | first4 = M. | last5 = Velu | first5 = T. | last6 = Heimann | first6 = R. | title = Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction. | journal = Am J Clin Pathol | volume = 103 | issue = 4 | pages = 449-52 | month = Apr | year = 1995 | doi = | PMID = 7726142 }}</ref> | |||
==Microscopic== | ==Microscopic== |
edits