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Difference between revisions of "Spermatocytic tumour"
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*CD117 -ve (7 positive/17). | *CD117 -ve (7 positive/17). | ||
*CAM5.2 -ve (1 positive/17). | *CAM5.2 -ve (1 positive/17). | ||
==Sign out== | |||
<pre> | |||
Left Testis, Radical Orchiectomy: | |||
- Spermatocytic tumour, see comment. | |||
- NEGATIVE for germ cell neoplasia in situ. | |||
- Background testis with spermatogenesis and atrophy. | |||
Comment: | |||
Spermatocytic tumours are rare. They are not associated with germ cell neoplasia in situ (GCNIS) and typically not seen together with other germ cell types. | |||
The tumour stains as follows: | |||
POSITIVE: CD117 (moderate, patchy), SALL4 (moderate, diffuse), CAM5.2 (dot-like staining), BCL2 (scattered cells, moderate membranous) | |||
NEGATIVE: AE1/AE3, AFP, CD31, CD34, calretinin, hCG, CD3, CD10, CD20, CD30, CD45, GATA3, PLAP, PSA, OCT3/4. | |||
This tumour (spermatoctyic tumour) was previously known as "spermatocytic seminoma". The term "spermatocytic seminoma" is no longer recommended by the WHO, presumably as the name may: (1) create confusion with "seminoma" and (2) falsely raise the possibility of a mixed tumour (that develops in the context of GCNIS). | |||
</pre> | |||
===Micro=== | |||
This tumour has three cell types with spireme chromatin in the larger and intermediate cell type. Infiltrating lymphocytes are absent. | |||
The background testis has some spermatogenesis and atrophic change. Germ cell neoplasia in situ (GCNIS) is ABSENT. The seminiferous tubules adjacent to the tumour, where visualized, are atrophic. | |||
==See also== | ==See also== | ||