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Difference between revisions of "Renal cell carcinoma with fibromyomatous stroma"
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Renal cell carcinoma with fibromyomatous stroma (view source)
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'''Renal cell carcinoma with fibromyomatous stroma''', abbreviated '''RCC FMS''', is an evolving subtype of [[renal cell carcinoma]].<ref>{{cite journal |vauthors=Trpkov K, Williamson SR, Gill AJ, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Hes O |title=Novel, emerging and provisional renal entities: The Genitourinary Pathology Society (GUPS) update on renal neoplasia |journal=Mod Pathol |volume=34 |issue=6 |pages=1167–1184 |date=June 2021 |pmid=33526874 |doi=10.1038/s41379-021-00737-6 |url=}}</ref> | '''Renal cell carcinoma with fibromyomatous stroma''', abbreviated '''RCC FMS''', is an evolving subtype of [[renal cell carcinoma]].<ref>{{cite journal |vauthors=Trpkov K, Williamson SR, Gill AJ, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Hes O |title=Novel, emerging and provisional renal entities: The Genitourinary Pathology Society (GUPS) update on renal neoplasia |journal=Mod Pathol |volume=34 |issue=6 |pages=1167–1184 |date=June 2021 |pmid=33526874 |doi=10.1038/s41379-021-00737-6 |url=}}</ref> | ||
==IHC== | |||
===Comparison between some renal tumours with clear cells=== | |||
{| class="wikitable sortable" | |||
!Tumour | |||
!CK7 | |||
!CD10 | |||
!CK34betaE12 (K903) | |||
!GPNMB | |||
|- | |||
|Clear cell renal cell carcinoma | |||
| -ve (may be focal) | |||
| +ve | |||
| -ve | |||
| usu. -ve | |||
|- | |||
|Clear cell papillary renal cell tumour | |||
| +ve (diffuse) | |||
| -ve | |||
| +ve | |||
| -ve<ref name=pmid37661807>{{cite journal |authors=Li H, Argani P, Halper-Stromberg E, Lotan TL, Merino MJ, Reuter VE, Matoso A |title=Positive GPNMB Immunostaining Differentiates Renal Cell Carcinoma With Fibromyomatous Stroma Associated With TSC1/2/MTOR Alterations From Others |journal=Am J Surg Pathol |volume=47 |issue=11 |pages=1267–1273 |date=November 2023 |pmid=37661807 |doi=10.1097/PAS.0000000000002117 |url=}}</ref> | |||
|- | |||
|ELOC-mutated renal cell carcinoma | |||
| +ve | |||
| +ve | |||
| -ve | |||
| -ve | |||
|- | |||
|TSC/mTOR-mutated renal cell carcinoma | |||
| +ve | |||
| +ve | |||
| -ve | |||
| +ve | |||
|- | |||
|} | |||