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Difference between revisions of "Foveolar type dysplasia"
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Foveolar type dysplasia (view source)
Revision as of 22:16, 18 December 2023
, 22:16, 18 December 2023+SO +IHC
(+SO +IHC) |
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| Line 40: | Line 40: | ||
Features: | Features: | ||
*Tall columnar cells with basal nuclei in a villiform architecture.<ref name=pmid20228780/> | *Tall columnar cells with basal nuclei in a villiform architecture.<ref name=pmid20228780/> | ||
*+/-Proliferative activity - mitotic figures. | |||
DDx: | DDx: | ||
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www: | www: | ||
*[http://www.nature.com/modpathol/journal/v23/n6/fig_tab/modpathol201059f2.html Foveolar type dysplasia of the esophagus (nature.com)].<ref name=pmid20228780>{{Cite journal | last1 = Brown | first1 = IS. | last2 = Whiteman | first2 = DC. | last3 = Lauwers | first3 = GY. | title = Foveolar type dysplasia in Barrett esophagus. | journal = Mod Pathol | volume = 23 | issue = 6 | pages = 834-43 | month = Jun | year = 2010 | doi = 10.1038/modpathol.2010.59 | PMID = 20228780 }}</ref> | *[http://www.nature.com/modpathol/journal/v23/n6/fig_tab/modpathol201059f2.html Foveolar type dysplasia of the esophagus (nature.com)].<ref name=pmid20228780>{{Cite journal | last1 = Brown | first1 = IS. | last2 = Whiteman | first2 = DC. | last3 = Lauwers | first3 = GY. | title = Foveolar type dysplasia in Barrett esophagus. | journal = Mod Pathol | volume = 23 | issue = 6 | pages = 834-43 | month = Jun | year = 2010 | doi = 10.1038/modpathol.2010.59 | PMID = 20228780 }}</ref> | ||
==IHC== | |||
Features:<ref name=pmid17419219>{{cite journal |authors=Testino G, Cornaggia M, Ferrando V |title=Low- and high-grade non-invasive gastric neoplasia (formerly dysplasia): cytological differentiation (gastro-entero-pancreatic antigens) in association with p53 pattern expression |journal=Hepatogastroenterology |volume=54 |issue=73 |pages=1–3 |date=2007 |pmid=17419219 |doi= |url=}}</ref> | |||
*p53 +ve. | |||
*Ki-67 increased staining in ~100% of cases. | |||
==Sign out== | |||
<pre> | |||
A. Polyp, Stomach, Biopsy or Polypectomy: | |||
- Polypoid fragment of gastric body type mucosa with low-grade DYSPLASIA, foveolar type, see comment. | |||
- NEGATIVE for Helicobacter-like organisms. | |||
- NEGATIVE for intestinal metaplasia. | |||
- NEGATIVE for evidence of malignancy. | |||
Comment: | |||
The sections show foveolar type epithelium with proliferation and hyperchromasia extending to the surface. A p53 and Ki-67 show diffuse staining in the abnormal epithelium. The architectural complexity is mild in the abnormal epithelium. Deepers were cut (x3); these are non-contributory. | |||
</pre> | |||
==See also== | ==See also== | ||