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Difference between revisions of "Medullary colorectal carcinoma"
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*CDX2, beta-catenin, MLH1 useful for differentiating from poorly differentiated colorectal carcinoma. | *CDX2, beta-catenin, MLH1 useful for differentiating from poorly differentiated colorectal carcinoma. | ||
*SMARCB1 loss - reported in one case.<ref name=pmid32083567>{{cite journal |authors=Melloul S, Mosnier JF, Masliah-Planchon J, Lepage C, Le Malicot K, Gornet JM, Edeline J, Dansette D, Texereau P, Delattre O, Laurent Puig P, Taieb J, Emile JF |title=Loss of SMARCB1 expression in colon carcinoma |journal=Cancer Biomark |volume=27 |issue=3 |pages=399–406 |date=2020 |pmid=32083567 |doi=10.3233/CBM-190287 |url=}}</ref> | *SMARCB1 loss - reported in one case.<ref name=pmid32083567>{{cite journal |authors=Melloul S, Mosnier JF, Masliah-Planchon J, Lepage C, Le Malicot K, Gornet JM, Edeline J, Dansette D, Texereau P, Delattre O, Laurent Puig P, Taieb J, Emile JF |title=Loss of SMARCB1 expression in colon carcinoma |journal=Cancer Biomark |volume=27 |issue=3 |pages=399–406 |date=2020 |pmid=32083567 |doi=10.3233/CBM-190287 |url=}}</ref> | ||
===Images=== | |||
<gallery> | |||
Image:Photomicrograph of colorectal medullary carcinoma x20a.jpg | Note numerous interspersed inflammatory cells (WC) | |||
Image:Photomicrograph of colorectal medullary carcinoma x20d.jpg | Note numerous interspersed inflammatory cells (WC) | |||
</gallery> | |||
<gallery> | |||
Image: Photomicrograph of medullary carcinoma at anorectum x4a.jpg | Medullary carcinoma - low mag. (WC) | |||
Image: Photomicrograph of medullary carcinoma at anorectum x20a.jpg | Medullary carcinoma - medium/high mag. (WC) | |||
Image: Photomicrograph of medullary carcinoma CK7 immunohistochemistry x20.png | CK7 negative (WC) | |||
Image: Photomicrograph of medullary carcinoma CK20 immunohistochemistry x20.png | CK20 negative (WC) | |||
Image: Photomicrograph of medullary carcinoma CDX2 immunohistochemistry x20.png | CDX2 variably positive (WC) | |||
Image: Photomicrograph of medullary carcinoma SATB2 immunohistochemistry x20.png | SATB2 positive (WC) | |||
Image: Photomicrograph of medullary carcinoma MLH1 immunohistochemistry x20.png | Loss of MLH1 expression (WC) | |||
Image: Photomicrograph of medullary carcinoma PMS2 immunohistochemistry x20.png | Loss of PMS2 expression (WC) | |||
Image: Photomicrograph of medullary carcinoma BRAF-VE1 immunohistochemistry x20.png | BRAF VE1 positive (WC) | |||
</gallery> | |||
==See also== | ==See also== | ||