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Difference between revisions of "Granulocytic sarcoma"
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add another image; other IHC markers
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Image:Chloroma_-_high_mag.jpg | Chloroma - high mag. (WC) | Image:Chloroma_-_high_mag.jpg | Chloroma - high mag. (WC) | ||
Image:Chloroma_-_very_high_mag.jpg | Chloroma - very high mag. (WC) | Image:Chloroma_-_very_high_mag.jpg | Chloroma - very high mag. (WC) | ||
Image:Myeloid sarcoma within a lymph node x40 magnification.jpg | Myeloid sarcoma within a lymph node (WC) | |||
</gallery> | </gallery> | ||
www: | www: | ||
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==IHC== | ==IHC== | ||
Features:<ref name=pmid24969631>{{Cite journal | last1 = Seifert | first1 = RP. | last2 = Bulkeley | first2 = W. | last3 = Zhang | first3 = L. | last4 = Menes | first4 = M. | last5 = Bui | first5 = MM. | title = A practical approach to diagnose soft tissue myeloid sarcoma preceding or coinciding with acute myeloid leukemia. | journal = Ann Diagn Pathol | volume = 18 | issue = 4 | pages = 253-60 | month = Aug | year = 2014 | doi = 10.1016/j.anndiagpath.2014.06.001 | PMID = 24969631 }}</ref> | Features:<ref name=pmid24969631>{{Cite journal | last1 = Seifert | first1 = RP. | last2 = Bulkeley | first2 = W. | last3 = Zhang | first3 = L. | last4 = Menes | first4 = M. | last5 = Bui | first5 = MM. | title = A practical approach to diagnose soft tissue myeloid sarcoma preceding or coinciding with acute myeloid leukemia. | journal = Ann Diagn Pathol | volume = 18 | issue = 4 | pages = 253-60 | month = Aug | year = 2014 | doi = 10.1016/j.anndiagpath.2014.06.001 | PMID = 24969631 }}</ref> | ||
Markers of immaturity: | |||
*CD34 +ve/-ve (5 of 9 cases). | |||
*CD117 +ve (9 of 9 cases). | *CD117 +ve (9 of 9 cases). | ||
*CD43 +ve (7 of 7 cases) | *TdT | ||
Myeloid markers: | |||
*CD43 +ve (7 of 7 cases) - sensitive, but not specific | |||
*Myeloperoxidase +ve (8 of 10 cases). | *Myeloperoxidase +ve (8 of 10 cases). | ||
*CD34 | *CD11c (myelomonocytic marker) | ||
*CD13 (granulopoietic marker) | |||
*CD33 (granulopoietic marker, specific but less sensitive) | |||
CD34, CD117 and myeloperoxidase are more commonly positive in cases showing granulopoietic differentiation, but can be negative in cases with a myelomonocytic or monocytic differentiation, where CD68, CD163 and lysozyme may be helpful.<ref name=pmid23530613>{{cite journal |vauthors=Zhou J, Bell D, Medeiros LJ |title=Myeloid sarcoma of the head and neck region |journal=Arch Pathol Lab Med |volume=137 |issue=11 |pages=1560–8 |date=November 2013 |pmid=23530613 |doi=10.5858/arpa.2012-0537-OA |url=}}</ref> | |||
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