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Difference between revisions of "Ependymoma"
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→Microscopic: Supratentorial ependymoma
Jensflorian (talk | contribs) (Update molecular classes.) |
Jensflorian (talk | contribs) (→Microscopic: Supratentorial ependymoma) |
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*Rare cases with cartilagineous metaplasia.<ref>{{Cite journal | last1 = Wang | first1 = X. | last2 = Zhang | first2 = S. | last3 = Ye | first3 = Y. | last4 = Chen | first4 = Y. | last5 = Liu | first5 = X. | title = Ependymoma with cartilaginous metaplasia might have more aggressive behavior: a case report and literature review. | journal = Brain Tumor Pathol | volume = 29 | issue = 3 | pages = 172-6 | month = Jul | year = 2012 | doi = 10.1007/s10014-011-0079-4 | PMID = 22228122 }}</ref> | *Rare cases with cartilagineous metaplasia.<ref>{{Cite journal | last1 = Wang | first1 = X. | last2 = Zhang | first2 = S. | last3 = Ye | first3 = Y. | last4 = Chen | first4 = Y. | last5 = Liu | first5 = X. | title = Ependymoma with cartilaginous metaplasia might have more aggressive behavior: a case report and literature review. | journal = Brain Tumor Pathol | volume = 29 | issue = 3 | pages = 172-6 | month = Jul | year = 2012 | doi = 10.1007/s10014-011-0079-4 | PMID = 22228122 }}</ref> | ||
*Branching capillaries usu. only in supratentorial ependymomas. | *Branching capillaries usu. only in supratentorial ependymomas. | ||
===Supratentorial ependymoma=== | |||
*Usu. connected to the ventricles. | |||
*Mostly frontal or temporal lobe. | |||
*Approx. 1/3 of all ependymal tumours (41% in children). | |||
*Irregular CM enhancement. | |||
*Cysts and/or calcification possible. | |||
*Sharply demarcated from adjacent brain parenchyma. | |||
*True ependymal rosettes are rare. | |||
*Occasionally branching capillary vessels. | |||
*Clear cell phenotypes more common than in other locations. | |||
*Complete surgical resection is the best predictor. | |||
*CSF spread in up to 15% of tumours. | |||
DDx (supratentorial and posterior fossa ependymoma): | DDx (supratentorial and posterior fossa ependymoma): | ||
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**Invasive border = GBM; circumscribed border of lesion = ependymoma. | **Invasive border = GBM; circumscribed border of lesion = ependymoma. | ||
*[[Oligodendroglioma]] (Clear cell ependymoma)) | *[[Oligodendroglioma]] (Clear cell ependymoma)) | ||
*CNS embryonal tumour with BCOR internal tandem duplication. | |||
DDx (spinal ependymoma): | DDx (spinal ependymoma): | ||