Account-creators
1,040
edits
Difference between revisions of "Oligodendroglioma"
Jump to navigation
Jump to search
Update
Jensflorian (talk | contribs) (→Molecular pathology: ref) |
Jensflorian (talk | contribs) (Update) |
||
| Line 30: | Line 30: | ||
| Tx = | | Tx = | ||
}} | }} | ||
'''Oligodendroglioma''' is [[CNS tumour]] that is typically in the cerebral hemispheres. Molecular analysis of IDH1/2 and LOH1p/19q testing is required for diagnosis. | '''Oligodendroglioma, IDH mutant and 1p/19q codeleted''' is [[CNS tumour]] that is typically in the cerebral hemispheres. Molecular analysis of IDH1/2 hotspots and LOH1p/19q testing is required for diagnosis. | ||
==General== | ==General== | ||
| Line 37: | Line 37: | ||
Prognosis by flavours (average survival):<ref name=Ref_PSNP98>{{Ref PSNP|98}}</ref> | Prognosis by flavours (average survival):<ref name=Ref_PSNP98>{{Ref PSNP|98}}</ref> | ||
*WHO grade | *WHO CNS grade 2: 10-15 years. | ||
*WHO grade | *WHO CNS grade 3: 3-5 years. | ||
Oligodendrogliomas account for approx 5% of all [[glioma]]s. | Oligodendrogliomas account for approx 5% of all [[glioma]]s. | ||
| Line 130: | Line 130: | ||
===Histologic grading=== | ===Histologic grading=== | ||
Come in two flavours: | Come in two flavours: | ||
# WHO grade | # WHO CNS grade 2 | ||
#*This is most oligodendrogliomas. | #*This is most oligodendrogliomas. | ||
#*Without genetic testing for [[IDH-1]]/2 and LOH 1p/19q, the tumor is called Oligodendroglioma, NOS. | #*Without genetic testing for [[IDH-1]]/2 and LOH 1p/19q, the tumor is called Oligodendroglioma, NOS. | ||
# WHO grade | # WHO CNS grade 3 | ||
#*Features for calling high grade:<ref name=Ref_PSNP98>{{Ref PSNP|98}}</ref> | #*Features for calling high grade:<ref name=Ref_PSNP98>{{Ref PSNP|98}}</ref> | ||
#**Endothelial hypertrophy. | #**Endothelial hypertrophy. | ||
| Line 164: | Line 164: | ||
Note: | Note: | ||
*Consider underdiagnosed Glioblastoma, IDH-wildtype when tumor is IDH1/2 wildtype and has no LOH 1p/19q and no ATRX loss. | *Consider underdiagnosed Glioblastoma, IDH-wildtype when tumor is IDH1/2 wildtype and has no LOH 1p/19q and no ATRX loss. | ||
*[[IDH-1]] mutant, but non-codeleted tumors are no longer classified as oligodendrogliomas on molecular basis. These tumors are classified | *[[IDH-1]] mutant, but non-codeleted tumors are no longer classified as oligodendrogliomas on molecular basis. These tumors are classified as IDH-mutant astrocytoma. | ||
==See also== | ==See also== | ||