48,830
edits
Difference between revisions of "Mesonephric adenocarcinoma"
Jump to navigation
Jump to search
Mesonephric adenocarcinoma (view source)
Revision as of 18:30, 17 November 2021
, 18:30, 17 November 2021split out
(redirect) |
(split out) Tag: Removed redirect |
||
| Line 1: | Line 1: | ||
'''Mesonephric adenocarcinoma''' is a rare malignant tumour of the [[uterine cervix]]. | |||
==General== | |||
*Arises from the [[mesonephric duct remnants]]. | |||
==Microscopic== | |||
Features:<ref name=Ref_WMSP442>{{Ref WMSP|442}}</ref> | |||
*Nuclear atypia - '''key feature'''. | |||
**Nuclear crowding. | |||
*Variable architecture: | |||
**Tubular, papillary, solid, retiform (net-like<ref>URL: [http://www.thefreedictionary.com/retiform http://www.thefreedictionary.com/retiform]. Accessed on: 25 August 2012.</ref>). | |||
DDx: | |||
*[[Mesonephric duct remnants]]. | |||
*[[Cervical adenocarcinoma]]. | |||
*[[Colorectal adenocarcinoma]]. | |||
*Endometrioid adenocarcinoma. | |||
*[[Clear cell adenocarcinoma of the uterus]]. | |||
==IHC== | |||
Features:<ref name=Ref_WMSP442>{{Ref WMSP|442}}</ref> | |||
*CK7 +ve. | |||
*CD10 +ve. | |||
*AMACR +ve. | |||
*Napsin A +ve.<ref name=pmid31361605>{{cite journal |authors=Pors J, Segura S, Cheng A, Ji JX, Tessier-Cloutier B, Cochrane D, Fix DJ, Park K, Gilks B, Hoang L |title=Napsin-A and AMACR are Superior to HNF-1β in Distinguishing Between Mesonephric Carcinomas and Clear Cell Carcinomas of the Gynecologic Tract |journal=Appl Immunohistochem Mol Morphol |volume=28 |issue=8 |pages=593–601 |date=September 2020 |pmid=31361605 |pmc=6987010 |doi=10.1097/PAI.0000000000000801 |url=}}</ref> | |||
*HNF-1beta +ve/-ve. | |||
**Not useful for differentiation from clear cell carcinoma of the gynecologic tract.<ref name=pmid31361605/> | |||
Others:<ref name=Ref_WMSP442>{{Ref WMSP|442}}</ref> | |||
*[[CK20]] -ve. | |||
*ER -ve. | |||
*PR -ve. | |||
*CEA -ve. | |||
==See also== | |||
*[[Gynecologic pathology]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||