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Difference between revisions of "Leiomyosarcoma"
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→Microscopic: more
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
#Cellular atypia - common. | *Cellular lesion. | ||
#Necrosis. | *Fasicular arrangement: | ||
#*Should be patchy/multifocal. | **Whorled look at low power. | ||
#*Zonal necrosis is suggestive of vascular cause. | **Groups of spindle cells cut peripendicular to their long axis adjacent to groups of spindle cells cut in the plane of their long axis. | ||
#Mitoses - '''key feature'''. | *Features of malignancy (need all three): | ||
#*10 mitoses/HPF. | *#Cellular atypia - common. | ||
#*5 mitoses/HPF - if epithelioid. | *#Necrosis. | ||
#*2 mitoses/HPF - if myxoid. | *#*Should be patchy/multifocal. | ||
#*>=1 mitosis/HPF - if cutaneous.<ref name=pmid21358302>{{cite journal |author=Kraft S, Fletcher CD |title=Atypical intradermal smooth muscle neoplasms: clinicopathologic analysis of 84 cases and a reappraisal of cutaneous "leiomyosarcoma" |journal=Am. J. Surg. Pathol. |volume=35 |issue=4 |pages=599–607 |year=2011 |month=April |pmid=21358302 |doi=10.1097/PAS.0b013e31820e6093 |url=}}</ref> | *#**Zonal necrosis is suggestive of vascular cause. | ||
*#Mitoses - '''key feature'''. | |||
*#*10 mitoses/HPF. | |||
*#*5 mitoses/HPF - if epithelioid. | |||
*#*2 mitoses/HPF - if myxoid. | |||
*#*>=1 mitosis/HPF - if cutaneous.<ref name=pmid21358302>{{cite journal |author=Kraft S, Fletcher CD |title=Atypical intradermal smooth muscle neoplasms: clinicopathologic analysis of 84 cases and a reappraisal of cutaneous "leiomyosarcoma" |journal=Am. J. Surg. Pathol. |volume=35 |issue=4 |pages=599–607 |year=2011 |month=April |pmid=21358302 |doi=10.1097/PAS.0b013e31820e6093 |url=}}</ref> | |||
===IHC=== | ===IHC=== | ||